Replication gap suppression depends on the double-strand DNA binding activity of BRCA2

Replication stress (RS) is a major source of genomic instability and is intrinsic to cancer cells. RS is also the consequence of chemotherapeutic drugs for treating cancer. However, adaptation to RS is also a mechanism of resistance to chemotherapy. BRCA2 deficiency results in replication stress in...

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Detalles Bibliográficos
Autores principales: Vugic, Domagoj, Dumoulin, Isaac, Martin, Charlotte, Minello, Anna, Alvaro-Aranda, Lucia, Gomez-Escudero, Jesus, Chaaban, Rady, Lebdy, Rana, von Nicolai, Catharina, Boucherit, Virginie, Ribeyre, Cyril, Constantinou, Angelos, Carreira, Aura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883520/
https://www.ncbi.nlm.nih.gov/pubmed/36707518
http://dx.doi.org/10.1038/s41467-023-36149-0

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