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Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research

BACKGROUND: Tumor treating fields (TTFields) is an FDA‐approved adjuvant therapy for glioblastoma. The distribution of an applied electric field has been shown to be governed by distinct tissue structures and electrical conductivity. Of all the tissues the skull plays a significant role in modifying...

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Autores principales: Jin, Taian, Dou, Zhangqi, Zhao, Yu, Jiang, Biao, Xu, Jinghong, Zhang, Buyi, Wei, Boxing, Dong, Fei, Zhang, Jianmin, Sun, Chongran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883554/
https://www.ncbi.nlm.nih.gov/pubmed/35861406
http://dx.doi.org/10.1002/cam4.5037
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author Jin, Taian
Dou, Zhangqi
Zhao, Yu
Jiang, Biao
Xu, Jinghong
Zhang, Buyi
Wei, Boxing
Dong, Fei
Zhang, Jianmin
Sun, Chongran
author_facet Jin, Taian
Dou, Zhangqi
Zhao, Yu
Jiang, Biao
Xu, Jinghong
Zhang, Buyi
Wei, Boxing
Dong, Fei
Zhang, Jianmin
Sun, Chongran
author_sort Jin, Taian
collection PubMed
description BACKGROUND: Tumor treating fields (TTFields) is an FDA‐approved adjuvant therapy for glioblastoma. The distribution of an applied electric field has been shown to be governed by distinct tissue structures and electrical conductivity. Of all the tissues the skull plays a significant role in modifying the distribution of the electric field due to its large impedance. In this study, we studied how remodeling of the skull would affect the therapeutic outcome of TTFields, using a computational approach. METHODS: Head models were created from the head template ICBM152 and five realistic head models. The electric field distribution was simulated using the default TTFields array layout. To study the impact of the skull on the electric field, we compared three cases, namely, intact skull, defective skull, and insulating process, wherein a thin electrical insulating layer was added between the transducer and the hydrogel. The electric field strength and heating power were calculated using the FEM (finite element method). RESULTS: Removing the skull flap increased the average field strength at the tumor site, without increasing the field strength of “brain”. The ATVs of the supratentorial tumors were enhanced significantly. Meanwhile, the heating power of the gels increased, especially those overlapping the skull defect site. Insulation lightly decreased the electric field strength and significantly decreased the heating power in deep tumor models. CONCLUSION: Our simulation results showed that a skull defect was beneficial for superficial tumors but had an adverse effect on deep tumors. Skull removal should be considered as an optional approach in future TTFields therapy to enhance its efficacy. An insulation process could be used as a joint option to reduce the thermogenic effect of skull defect. If excessive increase in heating power is observed in certain patients, insulating material could be used to mitigate overheating without sacrificing the therapeutic effect of TTFields.
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spelling pubmed-98835542023-01-31 Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research Jin, Taian Dou, Zhangqi Zhao, Yu Jiang, Biao Xu, Jinghong Zhang, Buyi Wei, Boxing Dong, Fei Zhang, Jianmin Sun, Chongran Cancer Med RESEARCH ARTICLES BACKGROUND: Tumor treating fields (TTFields) is an FDA‐approved adjuvant therapy for glioblastoma. The distribution of an applied electric field has been shown to be governed by distinct tissue structures and electrical conductivity. Of all the tissues the skull plays a significant role in modifying the distribution of the electric field due to its large impedance. In this study, we studied how remodeling of the skull would affect the therapeutic outcome of TTFields, using a computational approach. METHODS: Head models were created from the head template ICBM152 and five realistic head models. The electric field distribution was simulated using the default TTFields array layout. To study the impact of the skull on the electric field, we compared three cases, namely, intact skull, defective skull, and insulating process, wherein a thin electrical insulating layer was added between the transducer and the hydrogel. The electric field strength and heating power were calculated using the FEM (finite element method). RESULTS: Removing the skull flap increased the average field strength at the tumor site, without increasing the field strength of “brain”. The ATVs of the supratentorial tumors were enhanced significantly. Meanwhile, the heating power of the gels increased, especially those overlapping the skull defect site. Insulation lightly decreased the electric field strength and significantly decreased the heating power in deep tumor models. CONCLUSION: Our simulation results showed that a skull defect was beneficial for superficial tumors but had an adverse effect on deep tumors. Skull removal should be considered as an optional approach in future TTFields therapy to enhance its efficacy. An insulation process could be used as a joint option to reduce the thermogenic effect of skull defect. If excessive increase in heating power is observed in certain patients, insulating material could be used to mitigate overheating without sacrificing the therapeutic effect of TTFields. John Wiley and Sons Inc. 2022-07-21 /pmc/articles/PMC9883554/ /pubmed/35861406 http://dx.doi.org/10.1002/cam4.5037 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Jin, Taian
Dou, Zhangqi
Zhao, Yu
Jiang, Biao
Xu, Jinghong
Zhang, Buyi
Wei, Boxing
Dong, Fei
Zhang, Jianmin
Sun, Chongran
Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title_full Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title_fullStr Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title_full_unstemmed Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title_short Skull defect increases the tumor treating fields strength without detrimental thermogenic effect: A computational simulating research
title_sort skull defect increases the tumor treating fields strength without detrimental thermogenic effect: a computational simulating research
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883554/
https://www.ncbi.nlm.nih.gov/pubmed/35861406
http://dx.doi.org/10.1002/cam4.5037
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