Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

Tuberculosis, and especially multidrug-resistant tuberculosis (MDR-TB), is a major global health threat which emphasizes the need to develop new agents to improve and shorten treatment of this difficult-to-manage infectious disease. Among the new agents, macozinone (PBTZ169) is one of the most promi...

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Detalles Bibliográficos
Autores principales: Desfontaine, Vincent, Guinchard, Sylvie, Marques, Sara, Vocat, Anthony, Moulfi, Farizade, Versace, François, Huser-Pitteloud, Jeff, Ivanyuk, Anton, Bardinet, Carine, Makarov, Vadim, Ryabova, Olga, André, Pascal, Prod'Hom, Sylvain, Chtioui, Haithem, Buclin, Thierry, Cole, Stewart T., Decosterd, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883661/
https://www.ncbi.nlm.nih.gov/pubmed/36563654
http://dx.doi.org/10.1016/j.jchromb.2022.123555

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