An epitope-enriched immunogen expands responses to a conserved viral site

Pathogens evade host humoral responses by accumulating mutations in surface antigens. While variable, there are conserved regions that cannot mutate without compromising fitness. Antibodies targeting these conserved epitopes are often broadly protective but remain minor components of the repertoire....

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Detalles Bibliográficos
Autores principales: Caradonna, Timothy M., Ronsard, Larance, Yousif, Ashraf S., Windsor, Ian W., Hecht, Rachel, Bracamonte-Moreno, Thalia, Roffler, Anne A., Maron, Max J., Maurer, Daniel P., Feldman, Jared, Marchiori, Elisa, Barnes, Ralston M., Rohrer, Daniel, Lonberg, Nils, Oguin, Thomas H., Sempowski, Gregory D., Kepler, Thomas B., Kuraoka, Masayuki, Lingwood, Daniel, Schmidt, Aaron G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883670/
https://www.ncbi.nlm.nih.gov/pubmed/36351401
http://dx.doi.org/10.1016/j.celrep.2022.111628

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