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Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation

Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pha...

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Autores principales: Zhu, Ke, Yao, Yu, Wang, Kun, Shao, Fuqiang, Zhu, Ziyang, Song, Yangmeihui, Zhou, Zhangyongxue, Jiang, Dawei, Lan, Xiaoli, Qin, Chunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883926/
https://www.ncbi.nlm.nih.gov/pubmed/36709291
http://dx.doi.org/10.1186/s12951-023-01790-w
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author Zhu, Ke
Yao, Yu
Wang, Kun
Shao, Fuqiang
Zhu, Ziyang
Song, Yangmeihui
Zhou, Zhangyongxue
Jiang, Dawei
Lan, Xiaoli
Qin, Chunxia
author_facet Zhu, Ke
Yao, Yu
Wang, Kun
Shao, Fuqiang
Zhu, Ziyang
Song, Yangmeihui
Zhou, Zhangyongxue
Jiang, Dawei
Lan, Xiaoli
Qin, Chunxia
author_sort Zhu, Ke
collection PubMed
description Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01790-w.
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spelling pubmed-98839262023-01-29 Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation Zhu, Ke Yao, Yu Wang, Kun Shao, Fuqiang Zhu, Ziyang Song, Yangmeihui Zhou, Zhangyongxue Jiang, Dawei Lan, Xiaoli Qin, Chunxia J Nanobiotechnology Research Inflammatory regulation induced by macrophage polarization is essential for cardiac repair after myocardial infarction (MI). Berberin (BBR) is an isoquinoline tetrasystemic alkaloid extracted from plants. This study analyzes the most likely mechanism of BBR in MI treatment determined via network pharmacology, showing that BBR acts mainly through inflammatory responses. Because platelets (PLTs) can be enriched in the infarcted myocardium, PLT membrane-coated polylactic-co-glycolic acid (PLGA) nanoparticles (BBR@PLGA@PLT NPs) are used, which show enrichment in the infarcted myocardium to deliver BBR sustainably. Compared with PLGA nanoparticles, BBR@PLGA@PLT NPs are more enriched in the infarcted myocardium and exhibit less uptake in the liver. On day three after MI, BBR@PLGA@PLT NPs administration significantly increases the number of repaired macrophages and decreases the number of inflammatory macrophages and apoptotic cells in infarcted rat myocardium. On the 28th day after MI, the BBR@PLGA@PLT group exhibits a protective effect on cardiac function, reduced cardiac collagen deposition, improved scar tissue stiffness, and an excellent angiogenesis effect. In addition, BBR@PLGA@PLT group has no significant impact on major organs either histologically or enzymologically. In summary, the therapeutic effect of BBR@PLGA@PLT NPs on MI is presented in detail from the perspective of the resolution of inflammation, and a new solution for MI treatment is proposed. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01790-w. BioMed Central 2023-01-28 /pmc/articles/PMC9883926/ /pubmed/36709291 http://dx.doi.org/10.1186/s12951-023-01790-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhu, Ke
Yao, Yu
Wang, Kun
Shao, Fuqiang
Zhu, Ziyang
Song, Yangmeihui
Zhou, Zhangyongxue
Jiang, Dawei
Lan, Xiaoli
Qin, Chunxia
Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title_full Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title_fullStr Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title_full_unstemmed Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title_short Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
title_sort berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883926/
https://www.ncbi.nlm.nih.gov/pubmed/36709291
http://dx.doi.org/10.1186/s12951-023-01790-w
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