Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression

BACKGROUND: Lactate accumulation leads to an acidic tumor microenvironment (TME), in turn promoting colorectal cancer (CRC) progression. Tumor-associated macrophages (TAMs) are the predominant cells in TME. This study aimed to reveal the regulation mechanism of CRC cell-derived lactate on TAMs and e...

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Detalles Bibliográficos
Autores principales: Gao, Xinyi, Zhou, Shiqi, Qin, Zhaofu, Li, Dechuan, Zhu, Yuping, Ma, Dening
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883966/
https://www.ncbi.nlm.nih.gov/pubmed/36709284
http://dx.doi.org/10.1186/s12967-023-03918-w

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