Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

[Image: see text] PDE10A is an important regulator of striatal signaling that, when inhibited, can normalize dysfunctional activity. Given the involvement of dysfunctional striatal activity with schizophrenia, PDE10A inhibition represents a potentially novel means for its treatment. With the goal of...

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Detalles Bibliográficos
Autores principales: Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884086/
https://www.ncbi.nlm.nih.gov/pubmed/36624931
http://dx.doi.org/10.1021/acs.jmedchem.2c01521

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