Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist

[Image: see text] Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful conditions. Preclinical studies have demonstrated the role of TRPA1 receptors in a broad range of animal models of acute, inflam...

Descripción completa

Detalles Bibliográficos
Autores principales: Mesch, Stefanie, Walter, Daryl, Laux-Biehlmann, Alexis, Basting, Daniel, Flanagan, Stuart, Miyatake Ondozabal, Hideki, Bäurle, Stefan, Pearson, Christopher, Jenkins, James, Elves, Philip, Hess, Stephen, Coelho, Anne-Marie, Rotgeri, Andrea, Bothe, Ulrich, Nawaz, Schanila, Zollner, Thomas M., Steinmeyer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884088/
https://www.ncbi.nlm.nih.gov/pubmed/36622903
http://dx.doi.org/10.1021/acs.jmedchem.2c01830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884088/
https://www.ncbi.nlm.nih.gov/pubmed/36622903
http://dx.doi.org/10.1021/acs.jmedchem.2c01830

Ejemplares similares