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Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist
[Image: see text] Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful conditions. Preclinical studies have demonstrated the role of TRPA1 receptors in a broad range of animal models of acute, inflam...
Autores principales: | Mesch, Stefanie, Walter, Daryl, Laux-Biehlmann, Alexis, Basting, Daniel, Flanagan, Stuart, Miyatake Ondozabal, Hideki, Bäurle, Stefan, Pearson, Christopher, Jenkins, James, Elves, Philip, Hess, Stephen, Coelho, Anne-Marie, Rotgeri, Andrea, Bothe, Ulrich, Nawaz, Schanila, Zollner, Thomas M., Steinmeyer, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884088/ https://www.ncbi.nlm.nih.gov/pubmed/36622903 http://dx.doi.org/10.1021/acs.jmedchem.2c01830 |
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