Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening s...

Descripción completa

Detalles Bibliográficos
Autores principales: Molina, Guarina, Contreras, Rafael, Coombes, Kyle, Walgamage, Thilini, Perozo, Maria A, DesBiens, Martha T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Allergy/Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884115/
https://www.ncbi.nlm.nih.gov/pubmed/36721708
http://dx.doi.org/10.7759/cureus.34307
_version_ 1784879648745717760
author Molina, Guarina
Contreras, Rafael
Coombes, Kyle
Walgamage, Thilini
Perozo, Maria A
DesBiens, Martha T
author_facet Molina, Guarina
Contreras, Rafael
Coombes, Kyle
Walgamage, Thilini
Perozo, Maria A
DesBiens, Martha T
author_sort Molina, Guarina
collection PubMed
description Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition.
format Online
Article
Text
id pubmed-9884115
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-98841152023-01-30 Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection Molina, Guarina Contreras, Rafael Coombes, Kyle Walgamage, Thilini Perozo, Maria A DesBiens, Martha T Cureus Allergy/Immunology Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with multiple inflammatory symptoms involving several organ systems, including hematologic manifestations. Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome caused by excessive inflammation in the absence of immune regulation. We present the case of a patient with HLH secondary to dysregulated inflammatory response following COVID-19; we also describe the diagnostic and management challenges associated with the condition. Cureus 2023-01-28 /pmc/articles/PMC9884115/ /pubmed/36721708 http://dx.doi.org/10.7759/cureus.34307 Text en Copyright © 2023, Molina et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Allergy/Immunology
Molina, Guarina
Contreras, Rafael
Coombes, Kyle
Walgamage, Thilini
Perozo, Maria A
DesBiens, Martha T
Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title_full Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title_fullStr Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title_full_unstemmed Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title_short Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
title_sort hemophagocytic lymphohistiocytosis following covid-19 infection
topic Allergy/Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884115/
https://www.ncbi.nlm.nih.gov/pubmed/36721708
http://dx.doi.org/10.7759/cureus.34307
work_keys_str_mv AT molinaguarina hemophagocyticlymphohistiocytosisfollowingcovid19infection
AT contrerasrafael hemophagocyticlymphohistiocytosisfollowingcovid19infection
AT coombeskyle hemophagocyticlymphohistiocytosisfollowingcovid19infection
AT walgamagethilini hemophagocyticlymphohistiocytosisfollowingcovid19infection
AT perozomariaa hemophagocyticlymphohistiocytosisfollowingcovid19infection
AT desbiensmarthat hemophagocyticlymphohistiocytosisfollowingcovid19infection

Ejemplares similares