Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination

We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered secretion of the T cell-derived cytokine interleukin-2 ex vivo...

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Detalles Bibliográficos
Autores principales: Törnell, Andreas, Grauers Wiktorin, Hanna, Ringlander, Johan, Arabpour, Mohammad, Nilsson, Staffan, Lindh, Magnus, Lagging, Martin, Hellstrand, Kristoffer, Martner, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884141/
https://www.ncbi.nlm.nih.gov/pubmed/36720440
http://dx.doi.org/10.1016/j.clim.2023.109248
Descripción
Sumario:We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered secretion of the T cell-derived cytokine interleukin-2 ex vivo in 94/94 whole blood samples from vaccinated subjects at levels exceeding those recorded in all 45 pre-vaccination samples. S1-specific T cell reactivity was stronger in vaccinated subjects compared with subjects recovering from natural COVID-19 and decayed with an estimated half-life of 134 days in the first six months after the 2nd vaccination. We conclude that COVID-19 vaccination induces robust T cell immunity that subsequently declines. EudraCT 2021–000349-42. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2021-000349-42

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