Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination

We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered secretion of the T cell-derived cytokine interleukin-2 ex vivo...

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Autores principales: Törnell, Andreas, Grauers Wiktorin, Hanna, Ringlander, Johan, Arabpour, Mohammad, Nilsson, Staffan, Lindh, Magnus, Lagging, Martin, Hellstrand, Kristoffer, Martner, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884141/
https://www.ncbi.nlm.nih.gov/pubmed/36720440
http://dx.doi.org/10.1016/j.clim.2023.109248
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author Törnell, Andreas
Grauers Wiktorin, Hanna
Ringlander, Johan
Arabpour, Mohammad
Nilsson, Staffan
Lindh, Magnus
Lagging, Martin
Hellstrand, Kristoffer
Martner, Anna
author_facet Törnell, Andreas
Grauers Wiktorin, Hanna
Ringlander, Johan
Arabpour, Mohammad
Nilsson, Staffan
Lindh, Magnus
Lagging, Martin
Hellstrand, Kristoffer
Martner, Anna
author_sort Törnell, Andreas
collection PubMed
description We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered secretion of the T cell-derived cytokine interleukin-2 ex vivo in 94/94 whole blood samples from vaccinated subjects at levels exceeding those recorded in all 45 pre-vaccination samples. S1-specific T cell reactivity was stronger in vaccinated subjects compared with subjects recovering from natural COVID-19 and decayed with an estimated half-life of 134 days in the first six months after the 2nd vaccination. We conclude that COVID-19 vaccination induces robust T cell immunity that subsequently declines. EudraCT 2021–000349-42. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2021-000349-42
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spelling pubmed-98841412023-01-30 Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination Törnell, Andreas Grauers Wiktorin, Hanna Ringlander, Johan Arabpour, Mohammad Nilsson, Staffan Lindh, Magnus Lagging, Martin Hellstrand, Kristoffer Martner, Anna Clin Immunol Article We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered secretion of the T cell-derived cytokine interleukin-2 ex vivo in 94/94 whole blood samples from vaccinated subjects at levels exceeding those recorded in all 45 pre-vaccination samples. S1-specific T cell reactivity was stronger in vaccinated subjects compared with subjects recovering from natural COVID-19 and decayed with an estimated half-life of 134 days in the first six months after the 2nd vaccination. We conclude that COVID-19 vaccination induces robust T cell immunity that subsequently declines. EudraCT 2021–000349-42. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2021-000349-42 The Authors. Published by Elsevier Inc. 2023-03 2023-01-28 /pmc/articles/PMC9884141/ /pubmed/36720440 http://dx.doi.org/10.1016/j.clim.2023.109248 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Törnell, Andreas
Grauers Wiktorin, Hanna
Ringlander, Johan
Arabpour, Mohammad
Nilsson, Staffan
Lindh, Magnus
Lagging, Martin
Hellstrand, Kristoffer
Martner, Anna
Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title_full Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title_fullStr Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title_full_unstemmed Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title_short Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
title_sort induction and subsequent decline of s1-specific t cell reactivity after covid-19 vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884141/
https://www.ncbi.nlm.nih.gov/pubmed/36720440
http://dx.doi.org/10.1016/j.clim.2023.109248
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