Synthesis, properties, and application of the new nanocatalyst of double layer hydroxides in the one-pot multicomponent synthesis of 2-amino-3-cyanopyridine derivatives

A new heterogeneous nanocatalyst LDH@3-chloropyltrimethoxysilane@1,3-benzenedisulfonyl amine@Cu (LDH@TRMS@BDSA@Cu) was synthesized and confirmed by analyzes such as Fourier transform infrared spectroscopy, Field Emission Scanning Electron Microscopy, energy scattered X-ray spectroscopy (EDX), elemental mapping, X-ray diffraction analysis, heat gravity/heat derivatization (TGA) and differential scanning calorimetry. The newly synthesized nanocatalyst effectively catalyzed the reaction between different aryl aldehydes, malononitrile, different acetophenones and ammonium acetate in solvent-free conditions and they were converted into 2-amino-3-cyanopyridine derivatives with high efficiency. The reaction showed advantages such as simplicity, high stability, environmental friendliness, excellent efficiency and short time. Also, this catalyst is recyclable and was recycled 4 times without losing significant catalytic power.