Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Oncogenic KRAS expression generates a metabolic dependency on aerobic glycolysis, known as the Warburg effect. We report an effect of increased glycolytic flux that feeds into glycosphingolipid biosynthesis and is directly linked to KRAS oncogenic function. High resolution imaging and genetic approa...

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Detalles Bibliográficos
Autores principales: Liu, Junchen, van der Hoeven, Ransome, Kattan, Walaa E., Chang, Jeffrey T., Montufar-Solis, Dina, Chen, Wei, Wong, Maurice, Zhou, Yong, Lebrilla, Carlito B., Hancock, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884228/
https://www.ncbi.nlm.nih.gov/pubmed/36709325
http://dx.doi.org/10.1038/s41467-023-36128-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884228/
https://www.ncbi.nlm.nih.gov/pubmed/36709325
http://dx.doi.org/10.1038/s41467-023-36128-5

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