Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collec...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabharwal, Vishakha, Demos, Riley, Snyder-Cappione, Jennifer, Parker, Samantha E., Shaik-Dasthagirisaheb, Yazdan, Hunnewell, Jessica, Boateng, Jeffery, Clarke, Katherine, Yuen, Rachel, Barnett, Elizabeth, Yarrington, Christina, Taglauer, Elizabeth, Wachman, Elisha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884398/
https://www.ncbi.nlm.nih.gov/pubmed/36764228
http://dx.doi.org/10.1016/j.jri.2023.103821
_version_ 1784879709768646656
author Sabharwal, Vishakha
Demos, Riley
Snyder-Cappione, Jennifer
Parker, Samantha E.
Shaik-Dasthagirisaheb, Yazdan
Hunnewell, Jessica
Boateng, Jeffery
Clarke, Katherine
Yuen, Rachel
Barnett, Elizabeth
Yarrington, Christina
Taglauer, Elizabeth
Wachman, Elisha M.
author_facet Sabharwal, Vishakha
Demos, Riley
Snyder-Cappione, Jennifer
Parker, Samantha E.
Shaik-Dasthagirisaheb, Yazdan
Hunnewell, Jessica
Boateng, Jeffery
Clarke, Katherine
Yuen, Rachel
Barnett, Elizabeth
Yarrington, Christina
Taglauer, Elizabeth
Wachman, Elisha M.
author_sort Sabharwal, Vishakha
collection PubMed
description The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.
format Online
Article
Text
id pubmed-9884398
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-98843982023-01-30 Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls Sabharwal, Vishakha Demos, Riley Snyder-Cappione, Jennifer Parker, Samantha E. Shaik-Dasthagirisaheb, Yazdan Hunnewell, Jessica Boateng, Jeffery Clarke, Katherine Yuen, Rachel Barnett, Elizabeth Yarrington, Christina Taglauer, Elizabeth Wachman, Elisha M. J Reprod Immunol Short Communication The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants. Elsevier B.V. 2023-03 2023-01-29 /pmc/articles/PMC9884398/ /pubmed/36764228 http://dx.doi.org/10.1016/j.jri.2023.103821 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Sabharwal, Vishakha
Demos, Riley
Snyder-Cappione, Jennifer
Parker, Samantha E.
Shaik-Dasthagirisaheb, Yazdan
Hunnewell, Jessica
Boateng, Jeffery
Clarke, Katherine
Yuen, Rachel
Barnett, Elizabeth
Yarrington, Christina
Taglauer, Elizabeth
Wachman, Elisha M.
Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title_full Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title_fullStr Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title_full_unstemmed Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title_short Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls
title_sort cytokine levels in maternal and infant blood after covid-19 vaccination during pregnancy in comparison with unvaccinated controls
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884398/
https://www.ncbi.nlm.nih.gov/pubmed/36764228
http://dx.doi.org/10.1016/j.jri.2023.103821
work_keys_str_mv AT sabharwalvishakha cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT demosriley cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT snydercappionejennifer cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT parkersamanthae cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT shaikdasthagirisahebyazdan cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT hunnewelljessica cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT boatengjeffery cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT clarkekatherine cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT yuenrachel cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT barnettelizabeth cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT yarringtonchristina cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT taglauerelizabeth cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols
AT wachmanelisham cytokinelevelsinmaternalandinfantbloodaftercovid19vaccinationduringpregnancyincomparisonwithunvaccinatedcontrols

Ejemplares similares