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Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study

OBJECTIVES: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. METHODS: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The...

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Autores principales: Liu, Yazun, Xu, Lan, Piao, Xiang, Li, Han, Shi, Li, Huang, Yue, Zhou, Huan, Yang, Yan, Liu, Xiao, Wu, Mingyun, He, Yuanyuan, Yin, Yong, Wang, Libo, Yu, Jian, Zhou, Wenhao, Zheng, Junhua, Zhong, Victor W., Xue, Zheng, Zhong, Liwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884399/
https://www.ncbi.nlm.nih.gov/pubmed/36724865
http://dx.doi.org/10.1016/j.ijid.2023.01.030
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author Liu, Yazun
Xu, Lan
Piao, Xiang
Li, Han
Shi, Li
Huang, Yue
Zhou, Huan
Yang, Yan
Liu, Xiao
Wu, Mingyun
He, Yuanyuan
Yin, Yong
Wang, Libo
Yu, Jian
Zhou, Wenhao
Zheng, Junhua
Zhong, Victor W.
Xue, Zheng
Zhong, Liwei
author_facet Liu, Yazun
Xu, Lan
Piao, Xiang
Li, Han
Shi, Li
Huang, Yue
Zhou, Huan
Yang, Yan
Liu, Xiao
Wu, Mingyun
He, Yuanyuan
Yin, Yong
Wang, Libo
Yu, Jian
Zhou, Wenhao
Zheng, Junhua
Zhong, Victor W.
Xue, Zheng
Zhong, Liwei
author_sort Liu, Yazun
collection PubMed
description OBJECTIVES: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. METHODS: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed. RESULTS: In total, 2620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1011 (38.6%) were asymptomatic, whereas 1415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses, respectively. Household infection rate was negatively correlated with household vaccination coverage. Children aged 0-3 years, those who are unvaccinated, those with underlying diseases, and overweight/obese children had a higher risk of developing moderate to severe disease than children aged 12-17 years, those who were vaccinated, those without any underlying disease, and those with normal weight, respectively (all P <0.05). A prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all P <0.05). CONCLUSION: Children aged younger than 3 years who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level.
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spelling pubmed-98843992023-01-30 Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study Liu, Yazun Xu, Lan Piao, Xiang Li, Han Shi, Li Huang, Yue Zhou, Huan Yang, Yan Liu, Xiao Wu, Mingyun He, Yuanyuan Yin, Yong Wang, Libo Yu, Jian Zhou, Wenhao Zheng, Junhua Zhong, Victor W. Xue, Zheng Zhong, Liwei Int J Infect Dis Article OBJECTIVES: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. METHODS: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed. RESULTS: In total, 2620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1011 (38.6%) were asymptomatic, whereas 1415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses, respectively. Household infection rate was negatively correlated with household vaccination coverage. Children aged 0-3 years, those who are unvaccinated, those with underlying diseases, and overweight/obese children had a higher risk of developing moderate to severe disease than children aged 12-17 years, those who were vaccinated, those without any underlying disease, and those with normal weight, respectively (all P <0.05). A prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all P <0.05). CONCLUSION: Children aged younger than 3 years who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023-04 2023-01-29 /pmc/articles/PMC9884399/ /pubmed/36724865 http://dx.doi.org/10.1016/j.ijid.2023.01.030 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Liu, Yazun
Xu, Lan
Piao, Xiang
Li, Han
Shi, Li
Huang, Yue
Zhou, Huan
Yang, Yan
Liu, Xiao
Wu, Mingyun
He, Yuanyuan
Yin, Yong
Wang, Libo
Yu, Jian
Zhou, Wenhao
Zheng, Junhua
Zhong, Victor W.
Xue, Zheng
Zhong, Liwei
Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title_full Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title_fullStr Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title_full_unstemmed Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title_short Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
title_sort epidemiological, clinical, and household transmission characteristics of children and adolescents infected with sars-cov-2 omicron variant in shanghai, china: a retrospective, multicenter observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884399/
https://www.ncbi.nlm.nih.gov/pubmed/36724865
http://dx.doi.org/10.1016/j.ijid.2023.01.030
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