G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells

BACKGROUND: The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2–7 (EGFRvIII) being amongst the most common genomic mutations. EGFRvIII is heterogeneously expressed in GBM. We already showed that EGFRvIII...

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Detalles Bibliográficos
Autores principales: Cetin, Meryem H., Rieckmann, Thorsten, Hoffer, Konstantin, Riepen, Britta, Christiansen, Sabrina, Gatzemeier, Fruzsina, Feyerabend, Simon, Schoof, Melanie, Schüller, Ulrich, Petersen, Cordula, Mynarek, Martin, Rothkamm, Kai, Kriegs, Malte, Struve, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884419/
https://www.ncbi.nlm.nih.gov/pubmed/36709315
http://dx.doi.org/10.1186/s13014-023-02210-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884419/
https://www.ncbi.nlm.nih.gov/pubmed/36709315
http://dx.doi.org/10.1186/s13014-023-02210-x

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