CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo programmed ribosomal frameshifting (PRF) at a conserved structural element. Although PRF is essential for coronavirus replicatio...

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Detalles Bibliográficos
Autores principales: Rehfeld, Frederick, Eitson, Jennifer L., Ohlson, Maikke B., Chang, Tsung-Cheng, Schoggins, John W., Mendell, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
https://www.ncbi.nlm.nih.gov/pubmed/36753415
http://dx.doi.org/10.1016/j.celrep.2023.112076

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