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Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation

High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and thes...

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Autores principales: Tanaka, Sébastien, Tymowski, Christian De, Tran-Dinh, Alexy, Meilhac, Olivier, Lortat-Jacob, Brice, Zappella, Nathalie, Jean-Baptiste, Sylvain, Robert, Tiphaine, Goletto, Tiphaine, Godet, Cendrine, Castier, Yves, Mal, Hervé, Mordant, Pierre, Atchade, Enora, Messika, Jonathan, Montravers, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884674/
https://www.ncbi.nlm.nih.gov/pubmed/36726695
http://dx.doi.org/10.3389/ti.2023.10841
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author Tanaka, Sébastien
Tymowski, Christian De
Tran-Dinh, Alexy
Meilhac, Olivier
Lortat-Jacob, Brice
Zappella, Nathalie
Jean-Baptiste, Sylvain
Robert, Tiphaine
Goletto, Tiphaine
Godet, Cendrine
Castier, Yves
Mal, Hervé
Mordant, Pierre
Atchade, Enora
Messika, Jonathan
Montravers, Philippe
author_facet Tanaka, Sébastien
Tymowski, Christian De
Tran-Dinh, Alexy
Meilhac, Olivier
Lortat-Jacob, Brice
Zappella, Nathalie
Jean-Baptiste, Sylvain
Robert, Tiphaine
Goletto, Tiphaine
Godet, Cendrine
Castier, Yves
Mal, Hervé
Mordant, Pierre
Atchade, Enora
Messika, Jonathan
Montravers, Philippe
author_sort Tanaka, Sébastien
collection PubMed
description High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary.
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spelling pubmed-98846742023-01-31 Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation Tanaka, Sébastien Tymowski, Christian De Tran-Dinh, Alexy Meilhac, Olivier Lortat-Jacob, Brice Zappella, Nathalie Jean-Baptiste, Sylvain Robert, Tiphaine Goletto, Tiphaine Godet, Cendrine Castier, Yves Mal, Hervé Mordant, Pierre Atchade, Enora Messika, Jonathan Montravers, Philippe Transpl Int Health Archive High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9884674/ /pubmed/36726695 http://dx.doi.org/10.3389/ti.2023.10841 Text en Copyright © 2023 Tanaka, Tymowski, Tran-Dinh, Meilhac, Lortat-Jacob, Zappella, Jean-Baptiste, Robert, Goletto, Godet, Castier, Mal, Mordant, Atchade, Messika, Montravers and the Bichat Lung Transplant Group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Tanaka, Sébastien
Tymowski, Christian De
Tran-Dinh, Alexy
Meilhac, Olivier
Lortat-Jacob, Brice
Zappella, Nathalie
Jean-Baptiste, Sylvain
Robert, Tiphaine
Goletto, Tiphaine
Godet, Cendrine
Castier, Yves
Mal, Hervé
Mordant, Pierre
Atchade, Enora
Messika, Jonathan
Montravers, Philippe
Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title_full Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title_fullStr Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title_full_unstemmed Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title_short Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
title_sort low hdl-cholesterol concentrations in lung transplant candidates are strongly associated with one-year mortality after lung transplantation
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884674/
https://www.ncbi.nlm.nih.gov/pubmed/36726695
http://dx.doi.org/10.3389/ti.2023.10841
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