Cargando…
Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and thes...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884674/ https://www.ncbi.nlm.nih.gov/pubmed/36726695 http://dx.doi.org/10.3389/ti.2023.10841 |
_version_ | 1784879769369706496 |
---|---|
author | Tanaka, Sébastien Tymowski, Christian De Tran-Dinh, Alexy Meilhac, Olivier Lortat-Jacob, Brice Zappella, Nathalie Jean-Baptiste, Sylvain Robert, Tiphaine Goletto, Tiphaine Godet, Cendrine Castier, Yves Mal, Hervé Mordant, Pierre Atchade, Enora Messika, Jonathan Montravers, Philippe |
author_facet | Tanaka, Sébastien Tymowski, Christian De Tran-Dinh, Alexy Meilhac, Olivier Lortat-Jacob, Brice Zappella, Nathalie Jean-Baptiste, Sylvain Robert, Tiphaine Goletto, Tiphaine Godet, Cendrine Castier, Yves Mal, Hervé Mordant, Pierre Atchade, Enora Messika, Jonathan Montravers, Philippe |
author_sort | Tanaka, Sébastien |
collection | PubMed |
description | High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary. |
format | Online Article Text |
id | pubmed-9884674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98846742023-01-31 Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation Tanaka, Sébastien Tymowski, Christian De Tran-Dinh, Alexy Meilhac, Olivier Lortat-Jacob, Brice Zappella, Nathalie Jean-Baptiste, Sylvain Robert, Tiphaine Goletto, Tiphaine Godet, Cendrine Castier, Yves Mal, Hervé Mordant, Pierre Atchade, Enora Messika, Jonathan Montravers, Philippe Transpl Int Health Archive High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9884674/ /pubmed/36726695 http://dx.doi.org/10.3389/ti.2023.10841 Text en Copyright © 2023 Tanaka, Tymowski, Tran-Dinh, Meilhac, Lortat-Jacob, Zappella, Jean-Baptiste, Robert, Goletto, Godet, Castier, Mal, Mordant, Atchade, Messika, Montravers and the Bichat Lung Transplant Group. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Tanaka, Sébastien Tymowski, Christian De Tran-Dinh, Alexy Meilhac, Olivier Lortat-Jacob, Brice Zappella, Nathalie Jean-Baptiste, Sylvain Robert, Tiphaine Goletto, Tiphaine Godet, Cendrine Castier, Yves Mal, Hervé Mordant, Pierre Atchade, Enora Messika, Jonathan Montravers, Philippe Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title | Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title_full | Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title_fullStr | Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title_full_unstemmed | Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title_short | Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation |
title_sort | low hdl-cholesterol concentrations in lung transplant candidates are strongly associated with one-year mortality after lung transplantation |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884674/ https://www.ncbi.nlm.nih.gov/pubmed/36726695 http://dx.doi.org/10.3389/ti.2023.10841 |
work_keys_str_mv | AT tanakasebastien lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT tymowskichristiande lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT trandinhalexy lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT meilhacolivier lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT lortatjacobbrice lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT zappellanathalie lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT jeanbaptistesylvain lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT roberttiphaine lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT golettotiphaine lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT godetcendrine lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT castieryves lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT malherve lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT mordantpierre lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT atchadeenora lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT messikajonathan lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT montraversphilippe lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation AT lowhdlcholesterolconcentrationsinlungtransplantcandidatesarestronglyassociatedwithoneyearmortalityafterlungtransplantation |