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Possibilities of using T-cell biophysical biomarkers of ageing

Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal...

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Autores principales: González-Bermúdez, Blanca, Abarca-Ortega, Aldo, González-Sánchez, Mónica, De la Fuente, Mónica, Plaza, Gustavo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884748/
https://www.ncbi.nlm.nih.gov/pubmed/36111609
http://dx.doi.org/10.1017/erm.2022.29
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author González-Bermúdez, Blanca
Abarca-Ortega, Aldo
González-Sánchez, Mónica
De la Fuente, Mónica
Plaza, Gustavo R.
author_facet González-Bermúdez, Blanca
Abarca-Ortega, Aldo
González-Sánchez, Mónica
De la Fuente, Mónica
Plaza, Gustavo R.
author_sort González-Bermúdez, Blanca
collection PubMed
description Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete description of the changes at these levels would require extensive measurements of parameters and, furthermore, important fine details of the internal ordering that may be difficult to detect. Therefore, an alternative approach for the characterisation of cells consists of the performance of physical measurements of the whole cell, such as deformability measurements or migration measurements: the physical parameters, complementing the commonly used chemical biomarkers, may contribute to a better understanding of the evolution of T-cell states during ageing. Mechanical measurements, among other biophysical measurements, have the advantage of their relative simplicity: one single parameter agglutinates the complex effects of the variety of changes that gradually appear in cells during ageing.
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spelling pubmed-98847482023-02-08 Possibilities of using T-cell biophysical biomarkers of ageing González-Bermúdez, Blanca Abarca-Ortega, Aldo González-Sánchez, Mónica De la Fuente, Mónica Plaza, Gustavo R. Expert Rev Mol Med Review Ageing is interrelated with the development of immunosenescence. This article focuses on one of the cell sets of the adaptive immune system, T cells, and provides a review of the known changes in T cells associated with ageing. Such fundamental changes affect both cell molecular content and internal ordering. However, acquiring a complete description of the changes at these levels would require extensive measurements of parameters and, furthermore, important fine details of the internal ordering that may be difficult to detect. Therefore, an alternative approach for the characterisation of cells consists of the performance of physical measurements of the whole cell, such as deformability measurements or migration measurements: the physical parameters, complementing the commonly used chemical biomarkers, may contribute to a better understanding of the evolution of T-cell states during ageing. Mechanical measurements, among other biophysical measurements, have the advantage of their relative simplicity: one single parameter agglutinates the complex effects of the variety of changes that gradually appear in cells during ageing. Cambridge University Press 2022-09-16 /pmc/articles/PMC9884748/ /pubmed/36111609 http://dx.doi.org/10.1017/erm.2022.29 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Review
González-Bermúdez, Blanca
Abarca-Ortega, Aldo
González-Sánchez, Mónica
De la Fuente, Mónica
Plaza, Gustavo R.
Possibilities of using T-cell biophysical biomarkers of ageing
title Possibilities of using T-cell biophysical biomarkers of ageing
title_full Possibilities of using T-cell biophysical biomarkers of ageing
title_fullStr Possibilities of using T-cell biophysical biomarkers of ageing
title_full_unstemmed Possibilities of using T-cell biophysical biomarkers of ageing
title_short Possibilities of using T-cell biophysical biomarkers of ageing
title_sort possibilities of using t-cell biophysical biomarkers of ageing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884748/
https://www.ncbi.nlm.nih.gov/pubmed/36111609
http://dx.doi.org/10.1017/erm.2022.29
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