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TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes
Pregnancy is a complex biological process. The establishment and maintenance of foetal–maternal interface are pivotal events. Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal–maternal interface. The disfunction of decidual immune cells leads to adverse pregnanc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884758/ https://www.ncbi.nlm.nih.gov/pubmed/35687009 http://dx.doi.org/10.1017/erm.2022.18 |
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author | Dai, Fang-fang Hu, Min Zhang, Yu-wei Zhu, Rong-hui Chen, Li-ping Li, Zhi-dian Huang, Yan-jie Hu, Wei Cheng, Yan-xiang |
author_facet | Dai, Fang-fang Hu, Min Zhang, Yu-wei Zhu, Rong-hui Chen, Li-ping Li, Zhi-dian Huang, Yan-jie Hu, Wei Cheng, Yan-xiang |
author_sort | Dai, Fang-fang |
collection | PubMed |
description | Pregnancy is a complex biological process. The establishment and maintenance of foetal–maternal interface are pivotal events. Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal–maternal interface. The disfunction of decidual immune cells leads to adverse pregnancy outcome. Tumour necrosis factor (TNF)-α, a common inflammatory cytokine, has critical roles in different stages of normal pregnancy process. However, the relationship between the disorder of TNF-α and adverse pregnancy outcomes, including preeclampsia (PE), intrauterine growth restriction (IUGR), spontaneous abortion (SA), preterm birth and so on, is still indefinite. In this review, we thoroughly reviewed the effect of TNF-α disorder on pathological conditions. Moreover, we summarized the reports about the adverse pregnancy outcomes (PE, IUGR, SA and preterm birth) of using anti-TNF-α drugs (infliximab, etanercept and adalimumab, certolizumab and golimumab) currently in the clinical studies. Overall, IUGR, SA and preterm birth are the most common adverse pregnancy outcomes of anti-TNF-α drugs. Our review may provide insight for the immunological treatment of pregnancy-related complication, and help practitioners make informed decisions based on the current evidences. |
format | Online Article Text |
id | pubmed-9884758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98847582023-02-08 TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes Dai, Fang-fang Hu, Min Zhang, Yu-wei Zhu, Rong-hui Chen, Li-ping Li, Zhi-dian Huang, Yan-jie Hu, Wei Cheng, Yan-xiang Expert Rev Mol Med Review Pregnancy is a complex biological process. The establishment and maintenance of foetal–maternal interface are pivotal events. Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal–maternal interface. The disfunction of decidual immune cells leads to adverse pregnancy outcome. Tumour necrosis factor (TNF)-α, a common inflammatory cytokine, has critical roles in different stages of normal pregnancy process. However, the relationship between the disorder of TNF-α and adverse pregnancy outcomes, including preeclampsia (PE), intrauterine growth restriction (IUGR), spontaneous abortion (SA), preterm birth and so on, is still indefinite. In this review, we thoroughly reviewed the effect of TNF-α disorder on pathological conditions. Moreover, we summarized the reports about the adverse pregnancy outcomes (PE, IUGR, SA and preterm birth) of using anti-TNF-α drugs (infliximab, etanercept and adalimumab, certolizumab and golimumab) currently in the clinical studies. Overall, IUGR, SA and preterm birth are the most common adverse pregnancy outcomes of anti-TNF-α drugs. Our review may provide insight for the immunological treatment of pregnancy-related complication, and help practitioners make informed decisions based on the current evidences. Cambridge University Press 2022-06-10 /pmc/articles/PMC9884758/ /pubmed/35687009 http://dx.doi.org/10.1017/erm.2022.18 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Review Dai, Fang-fang Hu, Min Zhang, Yu-wei Zhu, Rong-hui Chen, Li-ping Li, Zhi-dian Huang, Yan-jie Hu, Wei Cheng, Yan-xiang TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title | TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title_full | TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title_fullStr | TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title_full_unstemmed | TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title_short | TNF-α/anti-TNF-α drugs and its effect on pregnancy outcomes |
title_sort | tnf-α/anti-tnf-α drugs and its effect on pregnancy outcomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884758/ https://www.ncbi.nlm.nih.gov/pubmed/35687009 http://dx.doi.org/10.1017/erm.2022.18 |
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