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Pharmacokinetics, tissue distribution, and antitumor activity of a novel compound, NY-2, in non-small cell lung cancer

Introduction: ZLDI-8, which has a relatively strong antitumor activity, is an inhibitor of ADAM-17 and acts on the Notch signaling pathway. To further optimize its structure and improve its activity, a series of derivatives of ZLDI-8 was synthesized. NY-2 was the most effective derivative based on p...

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Detalles Bibliográficos
Autores principales:	Zhang, Yingshi, Xu, Chang, Xu, Xiangbo, Ma, Lingxiang, Li, Ruolan, Xu, Zihua, Zhao, Qingchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884808/ https://www.ncbi.nlm.nih.gov/pubmed/36726788 http://dx.doi.org/10.3389/fphar.2022.1074576

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