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The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer

Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC. It seriously threatens the life and health of patients because of its early metastasis, late clinical...

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Autores principales: Sun, Yiyang, He, Ping, Li, Li, Ding, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884829/
https://www.ncbi.nlm.nih.gov/pubmed/36727069
http://dx.doi.org/10.3389/fonc.2022.969032
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author Sun, Yiyang
He, Ping
Li, Li
Ding, Xue
author_facet Sun, Yiyang
He, Ping
Li, Li
Ding, Xue
author_sort Sun, Yiyang
collection PubMed
description Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC. It seriously threatens the life and health of patients because of its early metastasis, late clinical symptoms, limited early screening methods, and poor treatment outcomes. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in cell proliferation, metastasis, and chemoresistance. Several previous studies have proven that ncRNAs are vital regulators of tumorigenesis. Ubiquitination plays the most crucial role in protein post-translational modification (PTM). Deubiquitination and ubiquitination form a homeostasis. In summary, ubiquitination and deubiquitination play essential roles in mediating the degradation or overexpression of a range of crucial proteins in various cancers. A growing number of researchers have found that interactions between ncRNAs and ubiquitination (or deubiquitination) play a crucial role in NSCLC. This review presents several typical examples of the important effects of ncRNAs and ubiquitination (or deubiquitination) in NSCLC, aiming to provide more creative ideas for exploring the diagnosis and treatment of NSCLC.
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spelling pubmed-98848292023-01-31 The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer Sun, Yiyang He, Ping Li, Li Ding, Xue Front Oncol Oncology Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC. It seriously threatens the life and health of patients because of its early metastasis, late clinical symptoms, limited early screening methods, and poor treatment outcomes. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), participate in cell proliferation, metastasis, and chemoresistance. Several previous studies have proven that ncRNAs are vital regulators of tumorigenesis. Ubiquitination plays the most crucial role in protein post-translational modification (PTM). Deubiquitination and ubiquitination form a homeostasis. In summary, ubiquitination and deubiquitination play essential roles in mediating the degradation or overexpression of a range of crucial proteins in various cancers. A growing number of researchers have found that interactions between ncRNAs and ubiquitination (or deubiquitination) play a crucial role in NSCLC. This review presents several typical examples of the important effects of ncRNAs and ubiquitination (or deubiquitination) in NSCLC, aiming to provide more creative ideas for exploring the diagnosis and treatment of NSCLC. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9884829/ /pubmed/36727069 http://dx.doi.org/10.3389/fonc.2022.969032 Text en Copyright © 2023 Sun, He, Li and Ding https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Sun, Yiyang
He, Ping
Li, Li
Ding, Xue
The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title_full The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title_fullStr The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title_full_unstemmed The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title_short The significance of the crosstalk between ubiquitination or deubiquitination and ncRNAs in non-small cell lung cancer
title_sort significance of the crosstalk between ubiquitination or deubiquitination and ncrnas in non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884829/
https://www.ncbi.nlm.nih.gov/pubmed/36727069
http://dx.doi.org/10.3389/fonc.2022.969032
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