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Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess pot...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884830/ https://www.ncbi.nlm.nih.gov/pubmed/36726470 http://dx.doi.org/10.3389/fendo.2022.1095211 |
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author | Arabi, Tarek Shafqat, Areez Sabbah, Belal Nedal Fawzy, Nader Ashraf Shah, Hassan Abdulkader, Humzah Razak, Adhil Sabbah, Ahmad Nedal Arabi, Ziad |
author_facet | Arabi, Tarek Shafqat, Areez Sabbah, Belal Nedal Fawzy, Nader Ashraf Shah, Hassan Abdulkader, Humzah Razak, Adhil Sabbah, Ahmad Nedal Arabi, Ziad |
author_sort | Arabi, Tarek |
collection | PubMed |
description | Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting a myriad of cytokines and adipokines that contribute to insulin resistance and induce a chronic low-grade inflammatory state thereby damaging the kidney. CKD development itself is associated with various metabolic alterations that exacerbate adipose tissue dysfunction and insulin resistance. This adipose-renal axis is a major focus of current research, given the rising incidence of CKD and obesity. Cellular senescence is a biologic hallmark of aging, and age is another significant risk factor for obesity and CKD. An elevated senescent cell burden in adipose tissue predicts renal dysfunction in animal models, and senotherapies may alleviate these phenotypes. In this review, we discuss the direct mechanisms by which adipose tissue contributes to CKD development, emphasizing the potential clinical importance of such pathways in augmenting the care of CKD. |
format | Online Article Text |
id | pubmed-9884830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98848302023-01-31 Obesity-related kidney disease: Beyond hypertension and insulin-resistance Arabi, Tarek Shafqat, Areez Sabbah, Belal Nedal Fawzy, Nader Ashraf Shah, Hassan Abdulkader, Humzah Razak, Adhil Sabbah, Ahmad Nedal Arabi, Ziad Front Endocrinol (Lausanne) Endocrinology Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting a myriad of cytokines and adipokines that contribute to insulin resistance and induce a chronic low-grade inflammatory state thereby damaging the kidney. CKD development itself is associated with various metabolic alterations that exacerbate adipose tissue dysfunction and insulin resistance. This adipose-renal axis is a major focus of current research, given the rising incidence of CKD and obesity. Cellular senescence is a biologic hallmark of aging, and age is another significant risk factor for obesity and CKD. An elevated senescent cell burden in adipose tissue predicts renal dysfunction in animal models, and senotherapies may alleviate these phenotypes. In this review, we discuss the direct mechanisms by which adipose tissue contributes to CKD development, emphasizing the potential clinical importance of such pathways in augmenting the care of CKD. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9884830/ /pubmed/36726470 http://dx.doi.org/10.3389/fendo.2022.1095211 Text en Copyright © 2023 Arabi, Shafqat, Sabbah, Fawzy, Shah, Abdulkader, Razak, Sabbah and Arabi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Arabi, Tarek Shafqat, Areez Sabbah, Belal Nedal Fawzy, Nader Ashraf Shah, Hassan Abdulkader, Humzah Razak, Adhil Sabbah, Ahmad Nedal Arabi, Ziad Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title_full | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title_fullStr | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title_full_unstemmed | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title_short | Obesity-related kidney disease: Beyond hypertension and insulin-resistance |
title_sort | obesity-related kidney disease: beyond hypertension and insulin-resistance |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884830/ https://www.ncbi.nlm.nih.gov/pubmed/36726470 http://dx.doi.org/10.3389/fendo.2022.1095211 |
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