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Influence of circadian clocks on adaptive immunity and vaccination responses
The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885059/ https://www.ncbi.nlm.nih.gov/pubmed/36717561 http://dx.doi.org/10.1038/s41467-023-35979-2 |
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author | Ince, Louise Madeleine Barnoud, Coline Lutes, Lydia Kay Pick, Robert Wang, Chen Sinturel, Flore Chen, Chien-Sin de Juan, Alba Weber, Jasmin Holtkamp, Stephan J. Hergenhan, Sophia Martina Geddes-McAlister, Jennifer Ebner, Stefan Fontannaz, Paola Meyer, Benjamin Vono, Maria Jemelin, Stéphane Dibner, Charna Siegrist, Claire-Anne Meissner, Felix Graw, Frederik Scheiermann, Christoph |
author_facet | Ince, Louise Madeleine Barnoud, Coline Lutes, Lydia Kay Pick, Robert Wang, Chen Sinturel, Flore Chen, Chien-Sin de Juan, Alba Weber, Jasmin Holtkamp, Stephan J. Hergenhan, Sophia Martina Geddes-McAlister, Jennifer Ebner, Stefan Fontannaz, Paola Meyer, Benjamin Vono, Maria Jemelin, Stéphane Dibner, Charna Siegrist, Claire-Anne Meissner, Felix Graw, Frederik Scheiermann, Christoph |
author_sort | Ince, Louise Madeleine |
collection | PubMed |
description | The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2. In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes. |
format | Online Article Text |
id | pubmed-9885059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98850592023-01-30 Influence of circadian clocks on adaptive immunity and vaccination responses Ince, Louise Madeleine Barnoud, Coline Lutes, Lydia Kay Pick, Robert Wang, Chen Sinturel, Flore Chen, Chien-Sin de Juan, Alba Weber, Jasmin Holtkamp, Stephan J. Hergenhan, Sophia Martina Geddes-McAlister, Jennifer Ebner, Stefan Fontannaz, Paola Meyer, Benjamin Vono, Maria Jemelin, Stéphane Dibner, Charna Siegrist, Claire-Anne Meissner, Felix Graw, Frederik Scheiermann, Christoph Nat Commun Article The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2. In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes. Nature Publishing Group UK 2023-01-30 /pmc/articles/PMC9885059/ /pubmed/36717561 http://dx.doi.org/10.1038/s41467-023-35979-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Ince, Louise Madeleine Barnoud, Coline Lutes, Lydia Kay Pick, Robert Wang, Chen Sinturel, Flore Chen, Chien-Sin de Juan, Alba Weber, Jasmin Holtkamp, Stephan J. Hergenhan, Sophia Martina Geddes-McAlister, Jennifer Ebner, Stefan Fontannaz, Paola Meyer, Benjamin Vono, Maria Jemelin, Stéphane Dibner, Charna Siegrist, Claire-Anne Meissner, Felix Graw, Frederik Scheiermann, Christoph Influence of circadian clocks on adaptive immunity and vaccination responses |
title | Influence of circadian clocks on adaptive immunity and vaccination responses |
title_full | Influence of circadian clocks on adaptive immunity and vaccination responses |
title_fullStr | Influence of circadian clocks on adaptive immunity and vaccination responses |
title_full_unstemmed | Influence of circadian clocks on adaptive immunity and vaccination responses |
title_short | Influence of circadian clocks on adaptive immunity and vaccination responses |
title_sort | influence of circadian clocks on adaptive immunity and vaccination responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885059/ https://www.ncbi.nlm.nih.gov/pubmed/36717561 http://dx.doi.org/10.1038/s41467-023-35979-2 |
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