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The mortality of patients with Parkinson's disease with deep brain stimulation

BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in improving motor function in patients with Parkinson's disease (PD). This study aimed to investigate mortality associated with bilateral STN DBS in patients with PD and to assess the factors associated with...

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Autores principales: Kim, Ahro, Kim, Han-Joon, Kim, Aryun, Kim, Yoon, Kim, Ahwon, Ong, Jed Noel A., Park, Hye Ran, Paek, Sun Ha, Jeon, Beomseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885091/
https://www.ncbi.nlm.nih.gov/pubmed/36726749
http://dx.doi.org/10.3389/fneur.2022.1099862
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author Kim, Ahro
Kim, Han-Joon
Kim, Aryun
Kim, Yoon
Kim, Ahwon
Ong, Jed Noel A.
Park, Hye Ran
Paek, Sun Ha
Jeon, Beomseok
author_facet Kim, Ahro
Kim, Han-Joon
Kim, Aryun
Kim, Yoon
Kim, Ahwon
Ong, Jed Noel A.
Park, Hye Ran
Paek, Sun Ha
Jeon, Beomseok
author_sort Kim, Ahro
collection PubMed
description BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in improving motor function in patients with Parkinson's disease (PD). This study aimed to investigate mortality associated with bilateral STN DBS in patients with PD and to assess the factors associated with mortality and causes of death after DBS. METHODS: We reviewed the medical records of 257 patients with PD who underwent bilateral STN DBS at the Movement Disorder Center at Seoul National University Hospital between March 2005 and November 2018. Patients were evaluated preoperatively, at 3, 6, and 12 months after surgery and annually thereafter. The cause and date of death were obtained from interviews with caregivers or from medical certificates at the last follow-up. RESULTS: Of the 257 patients with PD, 48 patients (18.7%) died, with a median time of death of 11.2 years after surgery. Pneumonia was the most common cause of death. Older age of disease onset, preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality in time-dependent Cox regression analysis. CONCLUSION: These results confirm the mortality outcome of STN DBS in patients with advanced PD.
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spelling pubmed-98850912023-01-31 The mortality of patients with Parkinson's disease with deep brain stimulation Kim, Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Ong, Jed Noel A. Park, Hye Ran Paek, Sun Ha Jeon, Beomseok Front Neurol Neurology BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in improving motor function in patients with Parkinson's disease (PD). This study aimed to investigate mortality associated with bilateral STN DBS in patients with PD and to assess the factors associated with mortality and causes of death after DBS. METHODS: We reviewed the medical records of 257 patients with PD who underwent bilateral STN DBS at the Movement Disorder Center at Seoul National University Hospital between March 2005 and November 2018. Patients were evaluated preoperatively, at 3, 6, and 12 months after surgery and annually thereafter. The cause and date of death were obtained from interviews with caregivers or from medical certificates at the last follow-up. RESULTS: Of the 257 patients with PD, 48 patients (18.7%) died, with a median time of death of 11.2 years after surgery. Pneumonia was the most common cause of death. Older age of disease onset, preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality in time-dependent Cox regression analysis. CONCLUSION: These results confirm the mortality outcome of STN DBS in patients with advanced PD. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9885091/ /pubmed/36726749 http://dx.doi.org/10.3389/fneur.2022.1099862 Text en Copyright © 2023 Kim, Kim, Kim, Kim, Kim, Ong, Park, Paek and Jeon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kim, Ahro
Kim, Han-Joon
Kim, Aryun
Kim, Yoon
Kim, Ahwon
Ong, Jed Noel A.
Park, Hye Ran
Paek, Sun Ha
Jeon, Beomseok
The mortality of patients with Parkinson's disease with deep brain stimulation
title The mortality of patients with Parkinson's disease with deep brain stimulation
title_full The mortality of patients with Parkinson's disease with deep brain stimulation
title_fullStr The mortality of patients with Parkinson's disease with deep brain stimulation
title_full_unstemmed The mortality of patients with Parkinson's disease with deep brain stimulation
title_short The mortality of patients with Parkinson's disease with deep brain stimulation
title_sort mortality of patients with parkinson's disease with deep brain stimulation
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885091/
https://www.ncbi.nlm.nih.gov/pubmed/36726749
http://dx.doi.org/10.3389/fneur.2022.1099862
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