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Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up
INTRODUCTION: Mitral regurgitation (MR) is a frequent complication in patients with severe aortic stenosis (AS). MATERIAL AND METHODS: Echocardiographic assessment of MR was performed at baseline, at 30 days and at 6 months after balloon aortic valvuloplasty (BAV). RESULTS: Data of 271 patients were...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885222/ https://www.ncbi.nlm.nih.gov/pubmed/36751280 http://dx.doi.org/10.5114/aic.2022.121004 |
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author | Kleczynski, Pawel Brzychczy, Piotr Kulbat, Aleksandra Wegrzyn, Jan Fijalkowski, Lukasz Okarski, Michał Mroz, Krystian Dziewierz, Artur Stapor, Maciej Trebacz, Jaroslaw Sorysz, Danuta Rzeszutko, Lukasz Bartus, Stanislaw Legutko, Jacek |
author_facet | Kleczynski, Pawel Brzychczy, Piotr Kulbat, Aleksandra Wegrzyn, Jan Fijalkowski, Lukasz Okarski, Michał Mroz, Krystian Dziewierz, Artur Stapor, Maciej Trebacz, Jaroslaw Sorysz, Danuta Rzeszutko, Lukasz Bartus, Stanislaw Legutko, Jacek |
author_sort | Kleczynski, Pawel |
collection | PubMed |
description | INTRODUCTION: Mitral regurgitation (MR) is a frequent complication in patients with severe aortic stenosis (AS). MATERIAL AND METHODS: Echocardiographic assessment of MR was performed at baseline, at 30 days and at 6 months after balloon aortic valvuloplasty (BAV). RESULTS: Data of 271 patients were included in our final analysis, of which 21.2% (n = 85) had at least moderate MR at baseline (in 19 (22.3%) subjects MR was diagnosed as primary). Both groups showed similar severity of AS, but patients in the MR group had a greater left ventricle (LV) size (p = 0.003 for LVESD, p = 0002 for LVEDD) and slightly lower LV ejection fraction (p = 0.04). Mitral regurgitation parameters significantly improved both at 30 days and 6 months after BAV in the MR group (MR jet area: 7.2 (4.5–9.9) vs. 3.6 (2.3–7.2) cm(2), and 7.2 (4.5–9.9) vs. 3.2 (2.1–6.7) cm(2); %MR/left atrial area 34.5 (23.4–42.7) vs. 17.5 (9.3–29.5) and 34.5 (23.4–42.7) vs. 14.5 (8.3–24.5), p < 0.001 for all). In multivariate logistic regression analysis, the change at 30 days, from baseline, in the LVESD (OR = 1.87; 95% CI: 1.23–2.87; p < 0.001) and LVEF (OR = 0.95; 95% CI: 0.87–1.01; p < 0.001); MR jet area (OR = 2.2, 95% CI: 1.5–4.6; p < 0.001) and the presence of primary MR (OR = 3.2, 95% CI: 1.04–5.98; p < 0.001) were retained as independent predictors of significant persisting MR at 6 months. CONCLUSIONS: Balloon aortic valvuloplasty may reduce MR in mid-term follow-up. Predictors of persistent MR at 6 months after BAV included an increase of LVESD and MR jet area and decrease of LVEF at 30 days. |
format | Online Article Text |
id | pubmed-9885222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-98852222023-02-06 Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up Kleczynski, Pawel Brzychczy, Piotr Kulbat, Aleksandra Wegrzyn, Jan Fijalkowski, Lukasz Okarski, Michał Mroz, Krystian Dziewierz, Artur Stapor, Maciej Trebacz, Jaroslaw Sorysz, Danuta Rzeszutko, Lukasz Bartus, Stanislaw Legutko, Jacek Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Mitral regurgitation (MR) is a frequent complication in patients with severe aortic stenosis (AS). MATERIAL AND METHODS: Echocardiographic assessment of MR was performed at baseline, at 30 days and at 6 months after balloon aortic valvuloplasty (BAV). RESULTS: Data of 271 patients were included in our final analysis, of which 21.2% (n = 85) had at least moderate MR at baseline (in 19 (22.3%) subjects MR was diagnosed as primary). Both groups showed similar severity of AS, but patients in the MR group had a greater left ventricle (LV) size (p = 0.003 for LVESD, p = 0002 for LVEDD) and slightly lower LV ejection fraction (p = 0.04). Mitral regurgitation parameters significantly improved both at 30 days and 6 months after BAV in the MR group (MR jet area: 7.2 (4.5–9.9) vs. 3.6 (2.3–7.2) cm(2), and 7.2 (4.5–9.9) vs. 3.2 (2.1–6.7) cm(2); %MR/left atrial area 34.5 (23.4–42.7) vs. 17.5 (9.3–29.5) and 34.5 (23.4–42.7) vs. 14.5 (8.3–24.5), p < 0.001 for all). In multivariate logistic regression analysis, the change at 30 days, from baseline, in the LVESD (OR = 1.87; 95% CI: 1.23–2.87; p < 0.001) and LVEF (OR = 0.95; 95% CI: 0.87–1.01; p < 0.001); MR jet area (OR = 2.2, 95% CI: 1.5–4.6; p < 0.001) and the presence of primary MR (OR = 3.2, 95% CI: 1.04–5.98; p < 0.001) were retained as independent predictors of significant persisting MR at 6 months. CONCLUSIONS: Balloon aortic valvuloplasty may reduce MR in mid-term follow-up. Predictors of persistent MR at 6 months after BAV included an increase of LVESD and MR jet area and decrease of LVEF at 30 days. Termedia Publishing House 2022-11-08 2022-09 /pmc/articles/PMC9885222/ /pubmed/36751280 http://dx.doi.org/10.5114/aic.2022.121004 Text en Copyright: © 2022 Termedia Sp. z o. o. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Kleczynski, Pawel Brzychczy, Piotr Kulbat, Aleksandra Wegrzyn, Jan Fijalkowski, Lukasz Okarski, Michał Mroz, Krystian Dziewierz, Artur Stapor, Maciej Trebacz, Jaroslaw Sorysz, Danuta Rzeszutko, Lukasz Bartus, Stanislaw Legutko, Jacek Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title | Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title_full | Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title_fullStr | Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title_full_unstemmed | Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title_short | Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
title_sort | balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885222/ https://www.ncbi.nlm.nih.gov/pubmed/36751280 http://dx.doi.org/10.5114/aic.2022.121004 |
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