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Exosomes and cancer immunotherapy: A review of recent cancer research

As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progre...

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Autores principales: Cao, Yue, Xu, Peng, Shen, Yangling, Wu, Wei, Chen, Min, Wang, Fei, Zhu, Yuandong, Yan, Feng, Gu, Weiying, Lin, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885269/
https://www.ncbi.nlm.nih.gov/pubmed/36727049
http://dx.doi.org/10.3389/fonc.2022.1118101
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author Cao, Yue
Xu, Peng
Shen, Yangling
Wu, Wei
Chen, Min
Wang, Fei
Zhu, Yuandong
Yan, Feng
Gu, Weiying
Lin, Yan
author_facet Cao, Yue
Xu, Peng
Shen, Yangling
Wu, Wei
Chen, Min
Wang, Fei
Zhu, Yuandong
Yan, Feng
Gu, Weiying
Lin, Yan
author_sort Cao, Yue
collection PubMed
description As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy.
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spelling pubmed-98852692023-01-31 Exosomes and cancer immunotherapy: A review of recent cancer research Cao, Yue Xu, Peng Shen, Yangling Wu, Wei Chen, Min Wang, Fei Zhu, Yuandong Yan, Feng Gu, Weiying Lin, Yan Front Oncol Oncology As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9885269/ /pubmed/36727049 http://dx.doi.org/10.3389/fonc.2022.1118101 Text en Copyright © 2023 Cao, Xu, Shen, Wu, Chen, Wang, Zhu, Yan, Gu and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cao, Yue
Xu, Peng
Shen, Yangling
Wu, Wei
Chen, Min
Wang, Fei
Zhu, Yuandong
Yan, Feng
Gu, Weiying
Lin, Yan
Exosomes and cancer immunotherapy: A review of recent cancer research
title Exosomes and cancer immunotherapy: A review of recent cancer research
title_full Exosomes and cancer immunotherapy: A review of recent cancer research
title_fullStr Exosomes and cancer immunotherapy: A review of recent cancer research
title_full_unstemmed Exosomes and cancer immunotherapy: A review of recent cancer research
title_short Exosomes and cancer immunotherapy: A review of recent cancer research
title_sort exosomes and cancer immunotherapy: a review of recent cancer research
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885269/
https://www.ncbi.nlm.nih.gov/pubmed/36727049
http://dx.doi.org/10.3389/fonc.2022.1118101
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