Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro

[Image: see text] The 3C-like protease (3CLpro) is an essential enzyme for the replication of SARS-CoV-2 and other coronaviruses and thus is a target for coronavirus drug discovery. Nearly all inhibitors of coronavirus 3CLpro reported so far are covalent inhibitors. Here, we report the development o...

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Detalles Bibliográficos
Autores principales: Hou, Ningke, Shuai, Lei, Zhang, Lijing, Xie, Xuping, Tang, Kaiming, Zhu, Yunkai, Yu, Yin, Zhang, Wenyi, Tan, Qiaozhu, Zhong, Gongxun, Wen, Zhiyuan, Wang, Chong, He, Xijun, Huo, Hong, Gao, Haishan, Xu, You, Xue, Jing, Peng, Chen, Zou, Jing, Schindewolf, Craig, Menachery, Vineet, Su, Wenji, Yuan, Youlang, Shen, Zuyuan, Zhang, Rong, Yuan, Shuofeng, Yu, Hongtao, Shi, Pei-Yong, Bu, Zhigao, Huang, Jing, Hu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885526/
https://www.ncbi.nlm.nih.gov/pubmed/36844503
http://dx.doi.org/10.1021/acscentsci.2c01359

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