14-3-3 proteins regulate cullin 7-mediated Eag1 degradation

BACKGROUND: Mutations in the human gene encoding the neuron-specific Eag1 (K(V)10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating function and defective protein homeostasis. Both the E3 ubiquitin ligase c...

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Detalles Bibliográficos
Autores principales: Hsieh, Chang-Heng, Chou, Chia-Cheng, Fang, Ya-Ching, Hsu, Po-Hao, Chiu, Yi-Hung, Yang, Chi-Sheng, Jow, Guey-Mei, Tang, Chih-Yung, Jeng, Chung-Jiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885684/
https://www.ncbi.nlm.nih.gov/pubmed/36717938
http://dx.doi.org/10.1186/s13578-023-00969-w

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