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Inhibition of 2-arachidonoylglycerol degradation enhances glial immunity by single-cell transcriptomic analysis

BACKGROUND: 2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid. Inhibition of 2-AG metabolism by inactivation of monoacylglycerol lipase (MAGL), the primary enzyme that degrades 2-AG in the brain, produces anti-inflammatory and neuroprotective effects in neurodegenerative dise...

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Detalles Bibliográficos
Autores principales:	Zhu, Dexiao, Zhang, Jian, Hashem, Jack, Gao, Fei, Chen, Chu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885699/ https://www.ncbi.nlm.nih.gov/pubmed/36717883 http://dx.doi.org/10.1186/s12974-023-02701-4

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