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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

BACKGROUND: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as the FKBP-ligand FK506 enhances BMP activity in various cell...

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Detalles Bibliográficos
Autores principales:	Quist-Løkken, Ingrid, Andersson-Rusch, Clara, Kastnes, Martin Haugrud, Kolos, Jürgen Markus, Jatzlau, Jerome, Hella, Hanne, Olsen, Oddrun Elise, Sundan, Anders, Knaus, Petra, Hausch, Felix, Holien, Toril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885706/ https://www.ncbi.nlm.nih.gov/pubmed/36717825 http://dx.doi.org/10.1186/s12964-022-01033-9

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