The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and cytokin...

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Autores principales: Giannotta, Claudia, Autino, Federica, Massaia, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885853/
https://www.ncbi.nlm.nih.gov/pubmed/36726975
http://dx.doi.org/10.3389/fimmu.2022.1102471
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author Giannotta, Claudia
Autino, Federica
Massaia, Massimo
author_facet Giannotta, Claudia
Autino, Federica
Massaia, Massimo
author_sort Giannotta, Claudia
collection PubMed
description Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, metabolic rewiring and exosome release. The two-way relationship between MDSC and tumor cells results in immune evasion and cancer outgrowth. In multiple myeloma (MM), MDSC play a major role in creating protumoral TME conditions. In this minireview, we will discuss the interplay between MDSC and MM TME and the possible strategies to target MDSC.
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spelling pubmed-98858532023-01-31 The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells Giannotta, Claudia Autino, Federica Massaia, Massimo Front Immunol Immunology Myeloid derived suppressors cells (MDSC) play major roles in regulating immune homeostasis and immune responses in many conditions, including cancer. MDSC interact with cancer cells within the tumor microenvironment (TME) with direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, metabolic rewiring and exosome release. The two-way relationship between MDSC and tumor cells results in immune evasion and cancer outgrowth. In multiple myeloma (MM), MDSC play a major role in creating protumoral TME conditions. In this minireview, we will discuss the interplay between MDSC and MM TME and the possible strategies to target MDSC. Frontiers Media S.A. 2023-01-16 /pmc/articles/PMC9885853/ /pubmed/36726975 http://dx.doi.org/10.3389/fimmu.2022.1102471 Text en Copyright © 2023 Giannotta, Autino and Massaia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Giannotta, Claudia
Autino, Federica
Massaia, Massimo
The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title_full The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title_fullStr The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title_full_unstemmed The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title_short The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells
title_sort immune suppressive tumor microenvironment in multiple myeloma: the contribution of myeloid-derived suppressor cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885853/
https://www.ncbi.nlm.nih.gov/pubmed/36726975
http://dx.doi.org/10.3389/fimmu.2022.1102471
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