Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue

Ultrasensitive sequential fluorescence in situ hybridization (USeqFISH) enables multiplexed detection of the expression of endogenous and exogenous genes delivered by adeno-associated virus (AAV) vectors in intact tissue. USeqFISH provides a spatial map of AAV tropism with high throughput and resolu...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885914/
https://www.ncbi.nlm.nih.gov/pubmed/36717693
http://dx.doi.org/10.1038/s41587-023-01681-3
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description Ultrasensitive sequential fluorescence in situ hybridization (USeqFISH) enables multiplexed detection of the expression of endogenous and exogenous genes delivered by adeno-associated virus (AAV) vectors in intact tissue. USeqFISH provides a spatial map of AAV tropism with high throughput and resolution.
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spelling pubmed-98859142023-01-30 Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue Nat Biotechnol Research Briefing Ultrasensitive sequential fluorescence in situ hybridization (USeqFISH) enables multiplexed detection of the expression of endogenous and exogenous genes delivered by adeno-associated virus (AAV) vectors in intact tissue. USeqFISH provides a spatial map of AAV tropism with high throughput and resolution. Nature Publishing Group US 2023-01-30 /pmc/articles/PMC9885914/ /pubmed/36717693 http://dx.doi.org/10.1038/s41587-023-01681-3 Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title_full Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title_fullStr Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title_full_unstemmed Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title_short Spatial tropism profiling of AAV vectors by ultrasensitive sequential FISH in tissue
title_sort spatial tropism profiling of aav vectors by ultrasensitive sequential fish in tissue
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885914/
https://www.ncbi.nlm.nih.gov/pubmed/36717693
http://dx.doi.org/10.1038/s41587-023-01681-3

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