Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB. In this work, we investigated the combination of anti-PD-1 and oncolytic measles vaccine in an i...

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Detalles Bibliográficos
Autores principales: Veinalde, Rūta, Pidelaserra-Martí, Gemma, Moulin, Coline, Tan, Chin Leng, Schäfer, Theresa E., Kang, Na, Ball, Claudia R., Leichsenring, Jonas, Stenzinger, Albrecht, Kaderali, Lars, Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886093/
https://www.ncbi.nlm.nih.gov/pubmed/36726983
http://dx.doi.org/10.3389/fimmu.2022.1096162

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