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Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie
In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Medizin
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886214/ https://www.ncbi.nlm.nih.gov/pubmed/36715732 http://dx.doi.org/10.1007/s00292-022-01178-x |
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author | Schänzer, Anne Dittmayer, Carsten Weis, Joachim Stenzel, Werner Goebel, Hans-Hilmar |
author_facet | Schänzer, Anne Dittmayer, Carsten Weis, Joachim Stenzel, Werner Goebel, Hans-Hilmar |
author_sort | Schänzer, Anne |
collection | PubMed |
description | In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic diseases, such as the lysosomal storage disease neuronal ceroid lipofuscinosis, are associated with pathognomonic storage products not only in the central nervous system (CNS) but also in extracerebral tissues such as sweat glands and lymphocytes. These tissues are easily accessible and thus function as “windows to the CNS”. In addition, there are new methods that overcome limitations of conventional electron microscopy and may improve ultrastructural diagnostics. This is particularly important for the correct classification of viral particles such as SARS-CoV‑2, leading to a better understanding of COVID19-associated diseases in the CNS and peripheral nervous system. |
format | Online Article Text |
id | pubmed-9886214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-98862142023-01-31 Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie Schänzer, Anne Dittmayer, Carsten Weis, Joachim Stenzel, Werner Goebel, Hans-Hilmar Pathologie (Heidelb) Schwerpunkt: Elektronenmikroskopie In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic diseases, such as the lysosomal storage disease neuronal ceroid lipofuscinosis, are associated with pathognomonic storage products not only in the central nervous system (CNS) but also in extracerebral tissues such as sweat glands and lymphocytes. These tissues are easily accessible and thus function as “windows to the CNS”. In addition, there are new methods that overcome limitations of conventional electron microscopy and may improve ultrastructural diagnostics. This is particularly important for the correct classification of viral particles such as SARS-CoV‑2, leading to a better understanding of COVID19-associated diseases in the CNS and peripheral nervous system. Springer Medizin 2023-01-30 2023 /pmc/articles/PMC9886214/ /pubmed/36715732 http://dx.doi.org/10.1007/s00292-022-01178-x Text en © The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Schwerpunkt: Elektronenmikroskopie Schänzer, Anne Dittmayer, Carsten Weis, Joachim Stenzel, Werner Goebel, Hans-Hilmar Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title | Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title_full | Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title_fullStr | Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title_full_unstemmed | Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title_short | Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems: Ausblick auf neue Techniken in der Elektronenmikroskopie |
title_sort | neuropathologie ii: erkrankungen des zentralen und peripheren nervensystems: ausblick auf neue techniken in der elektronenmikroskopie |
topic | Schwerpunkt: Elektronenmikroskopie |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886214/ https://www.ncbi.nlm.nih.gov/pubmed/36715732 http://dx.doi.org/10.1007/s00292-022-01178-x |
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