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Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

BACKGROUND: We have previously shown that the long non-coding (lnc)RNA prostate cancer associated 3 (PCA3; formerly prostate cancer antigen 3) functions as a trans-dominant negative oncogene by targeting the previously unrecognized prostate cancer suppressor gene PRUNE2 (a homolog of the Drosophila...

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Detalles Bibliográficos
Autores principales:	Lauer, Richard C, Barry, Marc, Smith, Tracey L, Thomas, Andrew Maltez, Wu, Jin, Du, Ruofei, Lee, Ji-Hyun, Rao, Arpit, Dobroff, Andrey S, Arap, Marco A, Nunes, Diana N, Silva, Israel T, Dias-Neto, Emmanuel, Chen, Isan, McCance, Dennis J, Cavenee, Webster K, Pasqualini, Renata, Arap, Wadih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886275/ https://www.ncbi.nlm.nih.gov/pubmed/36645410 http://dx.doi.org/10.7554/eLife.81929

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