Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine. The iPSCs exhibit a preference for lineage differentiation to the donor cell type indicating the existence of memory of origin. Although the intrinsic effect of the donor cell type on differentiation of iPSC...

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Detalles Bibliográficos
Autores principales: Khan, Nazir M, Diaz-Hernandez, Martha Elena, Chihab, Samir, Priyadarshani, Priyanka, Bhattaram, Pallavi, Mortensen, Luke J, Guzzo, Rosa M, Drissi, Hicham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886280/
https://www.ncbi.nlm.nih.gov/pubmed/36715686
http://dx.doi.org/10.7554/eLife.83138

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