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Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy

Intravesical instillation of bacillus Calmette-Guérin (BCG) is the adjuvant therapy for superficial urothelial carcinoma of the bladder with the lowest recurrence rates and is well tolerated with minor and self-limiting adverse effects. Serious complications, such as systemic BCG infection, are unco...

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Autores principales: Afonso, Raquel, Fontes, Joana, Pinto, Pedro, Romano, Miguel, Esteves, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886377/
https://www.ncbi.nlm.nih.gov/pubmed/36726926
http://dx.doi.org/10.7759/cureus.33134
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author Afonso, Raquel
Fontes, Joana
Pinto, Pedro
Romano, Miguel
Esteves, Alexandra
author_facet Afonso, Raquel
Fontes, Joana
Pinto, Pedro
Romano, Miguel
Esteves, Alexandra
author_sort Afonso, Raquel
collection PubMed
description Intravesical instillation of bacillus Calmette-Guérin (BCG) is the adjuvant therapy for superficial urothelial carcinoma of the bladder with the lowest recurrence rates and is well tolerated with minor and self-limiting adverse effects. Serious complications, such as systemic BCG infection, are uncommon as the diagnosis is difficult and, in the majority of cases, Mycobacterium bovis cannot be isolated. We describe a case of a man who presented with prolonged fever associated with polyuria, dysuria, anorexia, and significant weight loss, refractory to several courses of appropriate antibiotic therapy. After an exhaustive investigation, the underlying diagnosis of systemic BCG infection with renal involvement was considered. Antituberculosis treatment resulted in a marked clinical and radiological recovery, supporting this diagnosis.
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spelling pubmed-98863772023-01-31 Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy Afonso, Raquel Fontes, Joana Pinto, Pedro Romano, Miguel Esteves, Alexandra Cureus Urology Intravesical instillation of bacillus Calmette-Guérin (BCG) is the adjuvant therapy for superficial urothelial carcinoma of the bladder with the lowest recurrence rates and is well tolerated with minor and self-limiting adverse effects. Serious complications, such as systemic BCG infection, are uncommon as the diagnosis is difficult and, in the majority of cases, Mycobacterium bovis cannot be isolated. We describe a case of a man who presented with prolonged fever associated with polyuria, dysuria, anorexia, and significant weight loss, refractory to several courses of appropriate antibiotic therapy. After an exhaustive investigation, the underlying diagnosis of systemic BCG infection with renal involvement was considered. Antituberculosis treatment resulted in a marked clinical and radiological recovery, supporting this diagnosis. Cureus 2022-12-30 /pmc/articles/PMC9886377/ /pubmed/36726926 http://dx.doi.org/10.7759/cureus.33134 Text en Copyright © 2022, Afonso et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Afonso, Raquel
Fontes, Joana
Pinto, Pedro
Romano, Miguel
Esteves, Alexandra
Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title_full Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title_fullStr Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title_full_unstemmed Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title_short Systemic Bacillus Calmette-Guérin (BCG) Infection With Renal Involvement: A Rare Complication of BCG Immunotherapy
title_sort systemic bacillus calmette-guérin (bcg) infection with renal involvement: a rare complication of bcg immunotherapy
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886377/
https://www.ncbi.nlm.nih.gov/pubmed/36726926
http://dx.doi.org/10.7759/cureus.33134
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