The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy

The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differe...

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Autores principales: Lv, Changheng, Yang, Di, Zhang, Donghu, Shen, Jiajia, Wang, Zechen, He, Siyuan, Meng, Lingzhang, Song, Jian, Zhao, Jingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886469/
https://www.ncbi.nlm.nih.gov/pubmed/36726491
http://dx.doi.org/10.1155/2023/2623317
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author Lv, Changheng
Yang, Di
Zhang, Donghu
Shen, Jiajia
Wang, Zechen
He, Siyuan
Meng, Lingzhang
Song, Jian
Zhao, Jingjie
author_facet Lv, Changheng
Yang, Di
Zhang, Donghu
Shen, Jiajia
Wang, Zechen
He, Siyuan
Meng, Lingzhang
Song, Jian
Zhao, Jingjie
author_sort Lv, Changheng
collection PubMed
description The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differentially expressed genes in the cancerous biopsies isolated from gastric patients, compared with controls. Among which, ARMCX1 exhibited great potential to serve as a prognostic biomarker for gastric patients; furthermore, patients with low expression of ARMCX1 could be more sensitive to these 9 chemotherapeutic agents: A-770041, AMG-706, ATRA, BEZ235, bortezomib, CGP60474, dasatinib, HG-64-1, and pazopanib, rather than the other chemotherapeutic agents. This study helps the improvement of evaluating the prognosis of gastric cancer patients, and would help optimize chemotherapeutic strategies in consideration of the expression of ARMCX1.
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spelling pubmed-98864692023-01-31 The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy Lv, Changheng Yang, Di Zhang, Donghu Shen, Jiajia Wang, Zechen He, Siyuan Meng, Lingzhang Song, Jian Zhao, Jingjie J Immunol Res Research Article The altered expression of ARMCX1 in patients with gastric cancer has been reported frequently, yet its correlation to prognosis and chemotherapy needs to be unveiled. In combination of the gene expression data retrieved from TCGA database and bioinformatic analysis, this study discovered 590 differentially expressed genes in the cancerous biopsies isolated from gastric patients, compared with controls. Among which, ARMCX1 exhibited great potential to serve as a prognostic biomarker for gastric patients; furthermore, patients with low expression of ARMCX1 could be more sensitive to these 9 chemotherapeutic agents: A-770041, AMG-706, ATRA, BEZ235, bortezomib, CGP60474, dasatinib, HG-64-1, and pazopanib, rather than the other chemotherapeutic agents. This study helps the improvement of evaluating the prognosis of gastric cancer patients, and would help optimize chemotherapeutic strategies in consideration of the expression of ARMCX1. Hindawi 2023-01-23 /pmc/articles/PMC9886469/ /pubmed/36726491 http://dx.doi.org/10.1155/2023/2623317 Text en Copyright © 2023 Changheng Lv et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lv, Changheng
Yang, Di
Zhang, Donghu
Shen, Jiajia
Wang, Zechen
He, Siyuan
Meng, Lingzhang
Song, Jian
Zhao, Jingjie
The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title_full The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title_fullStr The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title_full_unstemmed The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title_short The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy
title_sort expression of armcx1 in gastric cancer contributes to prognosis and influences chemotherapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886469/
https://www.ncbi.nlm.nih.gov/pubmed/36726491
http://dx.doi.org/10.1155/2023/2623317
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