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Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide

INTRODUCTION: Among the fatty acid ethanolamides (FAEs), oleoylethanolamide (OEA), linoleoylethanolamide (LEA), and palmitoylethanolamide (PEA) are reported to be involved in feeding regulation. In particular, OEA is well characterized as a satiety signal. Following food consumption, OEA is synthesi...

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Autores principales: Igarashi, Miki, Iwasa, Kensuke, Hayakawa, Tetsuhiko, Tsuduki, Tsuyoshi, Kimura, Ikuo, Maruyama, Kei, Yoshikawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886573/
https://www.ncbi.nlm.nih.gov/pubmed/36733808
http://dx.doi.org/10.3389/fendo.2022.1056116
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author Igarashi, Miki
Iwasa, Kensuke
Hayakawa, Tetsuhiko
Tsuduki, Tsuyoshi
Kimura, Ikuo
Maruyama, Kei
Yoshikawa, Keisuke
author_facet Igarashi, Miki
Iwasa, Kensuke
Hayakawa, Tetsuhiko
Tsuduki, Tsuyoshi
Kimura, Ikuo
Maruyama, Kei
Yoshikawa, Keisuke
author_sort Igarashi, Miki
collection PubMed
description INTRODUCTION: Among the fatty acid ethanolamides (FAEs), oleoylethanolamide (OEA), linoleoylethanolamide (LEA), and palmitoylethanolamide (PEA) are reported to be involved in feeding regulation. In particular, OEA is well characterized as a satiety signal. Following food consumption, OEA is synthesized from oleic acid (OA) via an N-acyl phosphatidylethanolamine-specific phospholipase D-dependent pathway in the gastroenterocytes, and OEA induces satiety by recruiting sensory fibers. Thus, we hypothesized that dietary OA is an important satiety-inducing molecule. However, there has been no direct demonstration of the effect of dietary OA on satiety induction without the influence of the endogenous biosynthesis of OA from stearic acid (SA) or other FAEs. METHODS: In this study, we used two experimental diets to test our hypothesis: (i) an OA diet (OAD; 38.4 mg of OA/g and 7.2 mg of SA/g) and (ii) a low OA diet (LOAD; 3.1 mg of OA/g and 42.4 mg of SA/g). RESULTS: Relative to mice fed the OAD, mice fed the LOAD for two weeks exhibited reduced levels of jejunal OEA but not jejunal LEA and PEA. The LOAD-fed mice showed an increase in food intake and body weight gain. Moreover, LOAD-induced increase in food intake was immediately observed after the switch from the OAD, whereas these effects were diminished by the switch back to the OAD. Furthermore, treatment with OA and OEA diminished the effects of LOAD on food intake. CONCLUSION: Collectively, these results show that dietary OA is a key factor in the reduction of food intake and increase in satiety mediated by OEA signaling.
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spelling pubmed-98865732023-02-01 Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide Igarashi, Miki Iwasa, Kensuke Hayakawa, Tetsuhiko Tsuduki, Tsuyoshi Kimura, Ikuo Maruyama, Kei Yoshikawa, Keisuke Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Among the fatty acid ethanolamides (FAEs), oleoylethanolamide (OEA), linoleoylethanolamide (LEA), and palmitoylethanolamide (PEA) are reported to be involved in feeding regulation. In particular, OEA is well characterized as a satiety signal. Following food consumption, OEA is synthesized from oleic acid (OA) via an N-acyl phosphatidylethanolamine-specific phospholipase D-dependent pathway in the gastroenterocytes, and OEA induces satiety by recruiting sensory fibers. Thus, we hypothesized that dietary OA is an important satiety-inducing molecule. However, there has been no direct demonstration of the effect of dietary OA on satiety induction without the influence of the endogenous biosynthesis of OA from stearic acid (SA) or other FAEs. METHODS: In this study, we used two experimental diets to test our hypothesis: (i) an OA diet (OAD; 38.4 mg of OA/g and 7.2 mg of SA/g) and (ii) a low OA diet (LOAD; 3.1 mg of OA/g and 42.4 mg of SA/g). RESULTS: Relative to mice fed the OAD, mice fed the LOAD for two weeks exhibited reduced levels of jejunal OEA but not jejunal LEA and PEA. The LOAD-fed mice showed an increase in food intake and body weight gain. Moreover, LOAD-induced increase in food intake was immediately observed after the switch from the OAD, whereas these effects were diminished by the switch back to the OAD. Furthermore, treatment with OA and OEA diminished the effects of LOAD on food intake. CONCLUSION: Collectively, these results show that dietary OA is a key factor in the reduction of food intake and increase in satiety mediated by OEA signaling. Frontiers Media S.A. 2023-01-17 /pmc/articles/PMC9886573/ /pubmed/36733808 http://dx.doi.org/10.3389/fendo.2022.1056116 Text en Copyright © 2023 Igarashi, Iwasa, Hayakawa, Tsuduki, Kimura, Maruyama and Yoshikawa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Igarashi, Miki
Iwasa, Kensuke
Hayakawa, Tetsuhiko
Tsuduki, Tsuyoshi
Kimura, Ikuo
Maruyama, Kei
Yoshikawa, Keisuke
Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title_full Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title_fullStr Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title_full_unstemmed Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title_short Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
title_sort dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886573/
https://www.ncbi.nlm.nih.gov/pubmed/36733808
http://dx.doi.org/10.3389/fendo.2022.1056116
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