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CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer

BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common histological type of lung cancer, and brain metastasis (BM) is the most lethal complication of NSCLC. The predictive biomarkers and risk factors of asynchronous BM are still unknown. MATERIALS AND METHODS: A total of 203 patients with...

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Detalles Bibliográficos
Autores principales: Liang, Nan, Sun, Suohui, Li, Zheng, Wu, Tao, Zhang, Chunpu, Xin, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886659/
https://www.ncbi.nlm.nih.gov/pubmed/36733361
http://dx.doi.org/10.3389/fonc.2022.1098728
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author Liang, Nan
Sun, Suohui
Li, Zheng
Wu, Tao
Zhang, Chunpu
Xin, Tao
author_facet Liang, Nan
Sun, Suohui
Li, Zheng
Wu, Tao
Zhang, Chunpu
Xin, Tao
author_sort Liang, Nan
collection PubMed
description BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common histological type of lung cancer, and brain metastasis (BM) is the most lethal complication of NSCLC. The predictive biomarkers and risk factors of asynchronous BM are still unknown. MATERIALS AND METHODS: A total of 203 patients with NSCLC were enrolled into our cohort and followed up. The clinicopathological factors such as tumor size, T stage, lymphatic invasion, metastasis and asynchronous BM were investigated. CCKAR expression in NSCLC and resected BM was assessed by IHC, and CCKAR mRNAs in NSCLC and para-tumor tissues were estimated by qRT-PCR. The correlations between CCKAR expression, BM and other clinicopathological factors were assessed by chi-square test, and prognostic significance of CCKAR was estimated by univariate and multivariate analyses. RESULTS: CCKAR was highly expressed in NSCLC tissues compared with para-tumor tissues. CCKAR expression in NSCLC was significantly associated with asynchronous BM. The BM percentages for NSCLC patients with low and high CCKAR were surprisingly 5.2% and 66.6%, respectively. CCKAR expression and BM were unfavorable factors predicting unfavorable outcome of NSCLC. Moreover, CCKAR expression in NSCLC was an independent risk factor of asynchronous BM. CONCLUSIONS: CCKAR is a prognostic biomarker of NSCLC. CCKAR expression in NSCLC is positively associated with asynchronous BM, and is a risk factor of asynchronous BM from NSCLC.
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spelling pubmed-98866592023-02-01 CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer Liang, Nan Sun, Suohui Li, Zheng Wu, Tao Zhang, Chunpu Xin, Tao Front Oncol Oncology BACKGROUND: Non-small cell lung cancer (NSCLC) is the most common histological type of lung cancer, and brain metastasis (BM) is the most lethal complication of NSCLC. The predictive biomarkers and risk factors of asynchronous BM are still unknown. MATERIALS AND METHODS: A total of 203 patients with NSCLC were enrolled into our cohort and followed up. The clinicopathological factors such as tumor size, T stage, lymphatic invasion, metastasis and asynchronous BM were investigated. CCKAR expression in NSCLC and resected BM was assessed by IHC, and CCKAR mRNAs in NSCLC and para-tumor tissues were estimated by qRT-PCR. The correlations between CCKAR expression, BM and other clinicopathological factors were assessed by chi-square test, and prognostic significance of CCKAR was estimated by univariate and multivariate analyses. RESULTS: CCKAR was highly expressed in NSCLC tissues compared with para-tumor tissues. CCKAR expression in NSCLC was significantly associated with asynchronous BM. The BM percentages for NSCLC patients with low and high CCKAR were surprisingly 5.2% and 66.6%, respectively. CCKAR expression and BM were unfavorable factors predicting unfavorable outcome of NSCLC. Moreover, CCKAR expression in NSCLC was an independent risk factor of asynchronous BM. CONCLUSIONS: CCKAR is a prognostic biomarker of NSCLC. CCKAR expression in NSCLC is positively associated with asynchronous BM, and is a risk factor of asynchronous BM from NSCLC. Frontiers Media S.A. 2023-01-17 /pmc/articles/PMC9886659/ /pubmed/36733361 http://dx.doi.org/10.3389/fonc.2022.1098728 Text en Copyright © 2023 Liang, Sun, Li, Wu, Zhang and Xin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liang, Nan
Sun, Suohui
Li, Zheng
Wu, Tao
Zhang, Chunpu
Xin, Tao
CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title_full CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title_fullStr CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title_full_unstemmed CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title_short CCKAR is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
title_sort cckar is a biomarker for prognosis and asynchronous brain metastasis of non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886659/
https://www.ncbi.nlm.nih.gov/pubmed/36733361
http://dx.doi.org/10.3389/fonc.2022.1098728
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