Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk

The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patterns between 6,136 AD-affected and 10,555 AD-...

Descripción completa

Detalles Bibliográficos
Autores principales: Nazarian, Alireza, Philipp, Ian, Culminskaya, Irina, He, Liang, Kulminski, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886755/
https://www.ncbi.nlm.nih.gov/pubmed/35809216
http://dx.doi.org/10.1007/s11357-022-00617-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886755/
https://www.ncbi.nlm.nih.gov/pubmed/35809216
http://dx.doi.org/10.1007/s11357-022-00617-0

Ejemplares similares