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Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk

The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patterns between 6,136 AD-affected and 10,555 AD-...

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Detalles Bibliográficos
Autores principales:	Nazarian, Alireza, Philipp, Ian, Culminskaya, Irina, He, Liang, Kulminski, Alexander M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886755/ https://www.ncbi.nlm.nih.gov/pubmed/35809216 http://dx.doi.org/10.1007/s11357-022-00617-0

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