High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity

Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through which mitochondria impact human lifespan, however, remain unclear. We hypothesize that humans with exceptional longevity harbor rare variants in nuclear-encoded mitochondrial genes...

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Detalles Bibliográficos
Autores principales: Gonzalez, Brenda, Tare, Archana, Ryu, Seungjin, Johnson, Simon C., Atzmon, Gil, Barzilai, Nir, Kaeberlein, Matt, Suh, Yousin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886794/
https://www.ncbi.nlm.nih.gov/pubmed/35948858
http://dx.doi.org/10.1007/s11357-022-00634-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886794/
https://www.ncbi.nlm.nih.gov/pubmed/35948858
http://dx.doi.org/10.1007/s11357-022-00634-z

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