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Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism

Metabolic dysfunction, partly driven by altered liver function, predisposes to coronary artery disease (CAD), but the role of liver in vulnerable atherosclerotic plaque development remains unclear. Here we produced hepatocyte-like cells (HLCs) from 27 induced pluripotent stem cell (iPSC) lines deriv...

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Detalles Bibliográficos
Autores principales:	Alexanova, Anna, Raitoharju, Emma, Valtonen, Joona, Aalto-Setälä, Katriina, Viiri, Leena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886909/ https://www.ncbi.nlm.nih.gov/pubmed/36717592 http://dx.doi.org/10.1038/s41598-023-28981-7

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