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Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma
LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function and relative regulatory mechanism of LINC00941 in carcinogenesis of esophageal squamous cell carcinoma (ESCC) remain to be further clarified. The present study was...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886991/ https://www.ncbi.nlm.nih.gov/pubmed/36717549 http://dx.doi.org/10.1038/s41419-023-05605-6 |
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author | Lu, Jun-Tao Yan, Zhao-Yang Xu, Tong-Xin Zhao, Fan Liu, Lei Li, Fei Guo, Wei |
author_facet | Lu, Jun-Tao Yan, Zhao-Yang Xu, Tong-Xin Zhao, Fan Liu, Lei Li, Fei Guo, Wei |
author_sort | Lu, Jun-Tao |
collection | PubMed |
description | LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function and relative regulatory mechanism of LINC00941 in carcinogenesis of esophageal squamous cell carcinoma (ESCC) remain to be further clarified. The present study was to investigate the expression level, functions, and mechanisms of LINC00941 in ESCC tumorigenesis. LINC00941 was significantly upregulated in ESCC, and upregulated LINC00941 was correlated with dismal patient outcomes. LINC00941 functioned as an oncogene by promoting cells proliferation, stemness, migration, and invasion in ESCC. In terms of mechanisms, SOX2 could bind directly to the promoter region of LINC00941 and activate its transcription. In turn, LINC00941 upregulated SOX2 through interacting with interleukin enhancer binding factor 2 (ILF2) and Y-box binding protein 1 (YBX1) at the transcriptional and post-transcriptional levels. LINC00941 recruited ILF2 and YBX1 to the promoter region of SOX2, leading to upregulation of the transcription of SOX2. Moreover, LINC00941 could promote the binding ability of ILF2 and YBX1 on mRNA of SOX2 and further stabilize SOX2 mRNA. Therefore, LINC00941 contributed to the malignant behaviors of ESCC cells via the unrestricted increase in SOX2 expression. In conclusion, our data indicate that LINC00941 exacerbates ESCC progression through forming a LINC00941-ILF2/YBX1-SOX2 positive feedback loop, and LINC00941 may be a promising prognostic and therapeutic target for ESCC. |
format | Online Article Text |
id | pubmed-9886991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98869912023-02-01 Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma Lu, Jun-Tao Yan, Zhao-Yang Xu, Tong-Xin Zhao, Fan Liu, Lei Li, Fei Guo, Wei Cell Death Dis Article LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function and relative regulatory mechanism of LINC00941 in carcinogenesis of esophageal squamous cell carcinoma (ESCC) remain to be further clarified. The present study was to investigate the expression level, functions, and mechanisms of LINC00941 in ESCC tumorigenesis. LINC00941 was significantly upregulated in ESCC, and upregulated LINC00941 was correlated with dismal patient outcomes. LINC00941 functioned as an oncogene by promoting cells proliferation, stemness, migration, and invasion in ESCC. In terms of mechanisms, SOX2 could bind directly to the promoter region of LINC00941 and activate its transcription. In turn, LINC00941 upregulated SOX2 through interacting with interleukin enhancer binding factor 2 (ILF2) and Y-box binding protein 1 (YBX1) at the transcriptional and post-transcriptional levels. LINC00941 recruited ILF2 and YBX1 to the promoter region of SOX2, leading to upregulation of the transcription of SOX2. Moreover, LINC00941 could promote the binding ability of ILF2 and YBX1 on mRNA of SOX2 and further stabilize SOX2 mRNA. Therefore, LINC00941 contributed to the malignant behaviors of ESCC cells via the unrestricted increase in SOX2 expression. In conclusion, our data indicate that LINC00941 exacerbates ESCC progression through forming a LINC00941-ILF2/YBX1-SOX2 positive feedback loop, and LINC00941 may be a promising prognostic and therapeutic target for ESCC. Nature Publishing Group UK 2023-01-30 /pmc/articles/PMC9886991/ /pubmed/36717549 http://dx.doi.org/10.1038/s41419-023-05605-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lu, Jun-Tao Yan, Zhao-Yang Xu, Tong-Xin Zhao, Fan Liu, Lei Li, Fei Guo, Wei Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title | Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title_full | Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title_fullStr | Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title_full_unstemmed | Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title_short | Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma |
title_sort | reciprocal regulation of linc00941 and sox2 promotes progression of esophageal squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886991/ https://www.ncbi.nlm.nih.gov/pubmed/36717549 http://dx.doi.org/10.1038/s41419-023-05605-6 |
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