B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors

Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes identified by CRISPR/Cas9-mediated genome-wide knockout...

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Detalles Bibliográficos
Autores principales: Kaemena, Daniel F., Yoshihara, Masahito, Beniazza, Meryam, Ashmore, James, Zhao, Suling, Bertenstam, Mårten, Olariu, Victor, Katayama, Shintaro, Okita, Keisuke, Tomlinson, Simon R., Yusa, Kosuke, Kaji, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887000/
https://www.ncbi.nlm.nih.gov/pubmed/36717582
http://dx.doi.org/10.1038/s41467-023-36097-9

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