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Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) diseases that are caused by anomalous CAG triplet repeat expansions in several genes. SCA3 results from abnormal polyQ expansion in the deubiquitinase (DUB), ataxin-3 (Atxn3). To understand the role of the differ...

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Detalles Bibliográficos
Autores principales: Prifti, Matthew V., Libohova, Kozeta, Harris, Autumn L., Tsou, Wei-Ling, Todi, Sokol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887036/
https://www.ncbi.nlm.nih.gov/pubmed/36733922
http://dx.doi.org/10.3389/fnins.2022.1112688

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