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Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers

Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanis...

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Detalles Bibliográficos
Autores principales: Seo, Eunjeong, Kang, Minyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887101/
https://www.ncbi.nlm.nih.gov/pubmed/36476272
http://dx.doi.org/10.5483/BMBRep.2022-0200
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author Seo, Eunjeong
Kang, Minyong
author_facet Seo, Eunjeong
Kang, Minyong
author_sort Seo, Eunjeong
collection PubMed
description Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanisms of urological cancers. However, they cannot reflect biological phenotypes of real tissues and clinical diversities of urological cancers in vitro system. In vitro models cannot be utilized to reflect the tumor microenvironment or heterogeneity. Cancer organoids in three-dimensional culture have emerged as a promising platform for simulating tumor microenvironment and revealing heterogeneity. In this review, we summarize recent advances in prostate and kidney cancer organoids regarding culture conditions, advantages, and applications of these cancer organoids.
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spelling pubmed-98871012023-02-08 Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers Seo, Eunjeong Kang, Minyong BMB Rep Invited Mini Review Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanisms of urological cancers. However, they cannot reflect biological phenotypes of real tissues and clinical diversities of urological cancers in vitro system. In vitro models cannot be utilized to reflect the tumor microenvironment or heterogeneity. Cancer organoids in three-dimensional culture have emerged as a promising platform for simulating tumor microenvironment and revealing heterogeneity. In this review, we summarize recent advances in prostate and kidney cancer organoids regarding culture conditions, advantages, and applications of these cancer organoids. Korean Society for Biochemistry and Molecular Biology 2023-01-31 2022-12-02 /pmc/articles/PMC9887101/ /pubmed/36476272 http://dx.doi.org/10.5483/BMBRep.2022-0200 Text en Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Seo, Eunjeong
Kang, Minyong
Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title_full Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title_fullStr Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title_full_unstemmed Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title_short Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
title_sort current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887101/
https://www.ncbi.nlm.nih.gov/pubmed/36476272
http://dx.doi.org/10.5483/BMBRep.2022-0200
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