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Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers
Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanis...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887101/ https://www.ncbi.nlm.nih.gov/pubmed/36476272 http://dx.doi.org/10.5483/BMBRep.2022-0200 |
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author | Seo, Eunjeong Kang, Minyong |
author_facet | Seo, Eunjeong Kang, Minyong |
author_sort | Seo, Eunjeong |
collection | PubMed |
description | Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanisms of urological cancers. However, they cannot reflect biological phenotypes of real tissues and clinical diversities of urological cancers in vitro system. In vitro models cannot be utilized to reflect the tumor microenvironment or heterogeneity. Cancer organoids in three-dimensional culture have emerged as a promising platform for simulating tumor microenvironment and revealing heterogeneity. In this review, we summarize recent advances in prostate and kidney cancer organoids regarding culture conditions, advantages, and applications of these cancer organoids. |
format | Online Article Text |
id | pubmed-9887101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-98871012023-02-08 Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers Seo, Eunjeong Kang, Minyong BMB Rep Invited Mini Review Urological cancers such as kidney, bladder, prostate, and testicular cancers are the most common types of cancers worldwide with high mortality and morbidity. To date, traditional cell lines and animal models have been broadly used to study pre-clinical applications and underlying molecular mechanisms of urological cancers. However, they cannot reflect biological phenotypes of real tissues and clinical diversities of urological cancers in vitro system. In vitro models cannot be utilized to reflect the tumor microenvironment or heterogeneity. Cancer organoids in three-dimensional culture have emerged as a promising platform for simulating tumor microenvironment and revealing heterogeneity. In this review, we summarize recent advances in prostate and kidney cancer organoids regarding culture conditions, advantages, and applications of these cancer organoids. Korean Society for Biochemistry and Molecular Biology 2023-01-31 2022-12-02 /pmc/articles/PMC9887101/ /pubmed/36476272 http://dx.doi.org/10.5483/BMBRep.2022-0200 Text en Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Seo, Eunjeong Kang, Minyong Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title | Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title_full | Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title_fullStr | Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title_full_unstemmed | Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title_short | Current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
title_sort | current status and clinical application of patient-derived tumor organoid model in kidney and prostate cancers |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887101/ https://www.ncbi.nlm.nih.gov/pubmed/36476272 http://dx.doi.org/10.5483/BMBRep.2022-0200 |
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